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Fusion gene ID: 23929 |
FusionGeneSummary for NEBL_CAMK1D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEBL_CAMK1D | Fusion gene ID: 23929 | Hgene | Tgene | Gene symbol | NEBL | CAMK1D | Gene ID | 10529 | 57118 |
| Gene name | nebulette | calcium/calmodulin dependent protein kinase ID | |
| Synonyms | LASP2|LNEBL | CKLiK|CaM-K1|CaMKID | |
| Cytomap | 10p12.31 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk protein | calcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O76041 | Q8IU85 | |
| Ensembl transtripts involved in fusion gene | ENST00000377122, ENST00000417816, ENST00000377159, ENST00000377119, ENST00000464278, | ENST00000378847, ENST00000487696, ENST00000378845, | |
| Fusion gene scores | * DoF score | 8 X 7 X 4=224 | 8 X 9 X 6=432 |
| # samples | 10 | 10 | |
| ** MAII score | log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEBL [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CAMK1D | GO:0032793 | positive regulation of CREB transcription factor activity | 16324104 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-A8HD-01A | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000377122 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377122 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377122 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| In-frame | ENST00000417816 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| 5CDS-intron | ENST00000417816 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| 5CDS-intron | ENST00000417816 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-3CDS | ENST00000377159 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377159 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377159 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-3CDS | ENST00000377119 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377119 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000377119 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-3CDS | ENST00000464278 | ENST00000378847 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000464278 | ENST00000487696 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
| intron-intron | ENST00000464278 | ENST00000378845 | NEBL | chr10 | 21461312 | - | CAMK1D | chr10 | 12595224 | + |
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FusionProtFeatures for NEBL_CAMK1D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEBL | CAMK1D |