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Fusion gene ID: 23874 |
FusionGeneSummary for NDUFC2_AAMDC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDUFC2_AAMDC | Fusion gene ID: 23874 | Hgene | Tgene | Gene symbol | NDUFC2 | AAMDC | Gene ID | 4718 | 28971 |
| Gene name | NADH:ubiquinone oxidoreductase subunit C2 | adipogenesis associated Mth938 domain containing | |
| Synonyms | B14.5b|CI-B14.5b|HLC-1|NADHDH2 | C11orf67|CK067|PTD015 | |
| Cytomap | 11q14.1 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADH dehydrogenase [ubiquinone] 1 subunit C2NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDaNADH-ubiquinone oxidoreductase subunit B14.5bcomplex I subunit B14.5bcomplex I-B14.5bhuman lung cancer oncogene 1 protein | mth938 domain-containing proteinUPF0366 protein C11orf67adipogenesis associated Mth938 domain-containing protein | |
| Modification date | 20180527 | 20180524 | |
| UniProtAcc | O95298 | Q9H7C9 | |
| Ensembl transtripts involved in fusion gene | ENST00000281031, ENST00000527806, ENST00000534029, ENST00000525085, ENST00000528164, | ENST00000532481, ENST00000527134, ENST00000304716, ENST00000526415, ENST00000531855, ENST00000393427, ENST00000525409, ENST00000533193, ENST00000525034, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 5 X 5=200 |
| # samples | 1 | 9 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NDUFC2 [Title/Abstract] AND AAMDC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-GN-A26D-06A | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000281031 | ENST00000532481 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000527134 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000304716 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000526415 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000531855 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000393427 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000525409 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000533193 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000281031 | ENST00000525034 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| In-frame | ENST00000527806 | ENST00000532481 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000527134 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000304716 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000526415 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000531855 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000393427 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000525409 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000533193 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000527806 | ENST00000525034 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| In-frame | ENST00000534029 | ENST00000532481 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000527134 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000304716 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000526415 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000531855 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000393427 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000525409 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000533193 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000534029 | ENST00000525034 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| In-frame | ENST00000525085 | ENST00000532481 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000527134 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000304716 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000526415 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000531855 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000393427 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000525409 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000533193 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000525085 | ENST00000525034 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| In-frame | ENST00000528164 | ENST00000532481 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000527134 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000304716 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000526415 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000531855 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000393427 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000525409 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000533193 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
| 5CDS-intron | ENST00000528164 | ENST00000525034 | NDUFC2 | chr11 | 77790625 | - | AAMDC | chr11 | 77629107 | + |
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FusionProtFeatures for NDUFC2_AAMDC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDUFC2 | AAMDC |