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Fusion gene ID: 23850 |
FusionGeneSummary for NDUFAF2_NDUFAF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDUFAF2_NDUFAF2 | Fusion gene ID: 23850 | Hgene | Tgene | Gene symbol | NDUFAF2 | NDUFAF2 | Gene ID | 91942 | 91942 |
| Gene name | NADH:ubiquinone oxidoreductase complex assembly factor 2 | NADH:ubiquinone oxidoreductase complex assembly factor 2 | |
| Synonyms | B17.2L|MMTN|NDUFA12L|mimitin | B17.2L|MMTN|NDUFA12L|mimitin | |
| Cytomap | 5q12.1 | 5q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Myc-induced mitochondrial proteinNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2NADH dehydrogenase (ubiquinone) complex I, assembly factor 2NADH dehydrogenase 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8N183 | Q8N183 | |
| Ensembl transtripts involved in fusion gene | ENST00000296597, ENST00000511107, ENST00000512623, | ENST00000296597, ENST00000511107, ENST00000512623, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 6 X 4 X 3=72 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NDUFAF2 [Title/Abstract] AND NDUFAF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA526464 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000296597 | ENST00000296597 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000296597 | ENST00000511107 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000296597 | ENST00000512623 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000511107 | ENST00000296597 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000511107 | ENST00000511107 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000511107 | ENST00000512623 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000512623 | ENST00000296597 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000512623 | ENST00000511107 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
| intron-intron | ENST00000512623 | ENST00000512623 | NDUFAF2 | chr5 | 60334288 | + | NDUFAF2 | chr5 | 60334228 | - |
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FusionProtFeatures for NDUFAF2_NDUFAF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDUFAF2 | NDUFAF2 |