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Fusion gene ID: 2382 |
FusionGeneSummary for ARHGAP17_TNRC6A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGAP17_TNRC6A | Fusion gene ID: 2382 | Hgene | Tgene | Gene symbol | ARHGAP17 | TNRC6A | Gene ID | 55114 | 27327 |
| Gene name | Rho GTPase activating protein 17 | trinucleotide repeat containing 6A | |
| Synonyms | MST066|MST110|MSTP038|MSTP066|MSTP110|NADRIN|PP367|PP4534|RICH-1|RICH1|WBP15 | CAGH26|GW1|GW182|TNRC6 | |
| Cytomap | 16p12.1 | 16p12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein 17RhoGAP interacting with CIP4 homologs 1neuron-associated developmentally regulated proteinrho-type GTPase-activating protein 17 | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q68EM7 | Q8NDV7 | |
| Ensembl transtripts involved in fusion gene | ENST00000289968, ENST00000441763, ENST00000303665, ENST00000575975, | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 11 X 11 X 3=363 |
| # samples | 6 | 11 | |
| ** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/363*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGAP17 [Title/Abstract] AND TNRC6A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-S3-AA0Z-01A | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000289968 | ENST00000315183 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 5CDS-intron | ENST00000289968 | ENST00000562829 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 5CDS-intron | ENST00000289968 | ENST00000395799 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 5CDS-intron | ENST00000289968 | ENST00000432286 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 3UTR-3CDS | ENST00000441763 | ENST00000315183 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 3UTR-intron | ENST00000441763 | ENST00000562829 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 3UTR-intron | ENST00000441763 | ENST00000395799 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 3UTR-intron | ENST00000441763 | ENST00000432286 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| In-frame | ENST00000303665 | ENST00000315183 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 5CDS-intron | ENST00000303665 | ENST00000562829 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 5CDS-intron | ENST00000303665 | ENST00000395799 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| 5CDS-intron | ENST00000303665 | ENST00000432286 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| intron-3CDS | ENST00000575975 | ENST00000315183 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| intron-intron | ENST00000575975 | ENST00000562829 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| intron-intron | ENST00000575975 | ENST00000395799 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
| intron-intron | ENST00000575975 | ENST00000432286 | ARHGAP17 | chr16 | 24953308 | - | TNRC6A | chr16 | 24762047 | + |
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FusionProtFeatures for ARHGAP17_TNRC6A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGAP17 | TNRC6A |