|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23779 |
FusionGeneSummary for NDFIP1_SIK3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NDFIP1_SIK3 | Fusion gene ID: 23779 | Hgene | Tgene | Gene symbol | NDFIP1 | SIK3 | Gene ID | 80762 | 23387 |
| Gene name | Nedd4 family interacting protein 1 | SIK family kinase 3 | |
| Synonyms | N4WBP5 | L19|QSK|SIK-3 | |
| Cytomap | 5q31.3 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NEDD4 family-interacting protein 1Nedd4 WW domain-binding protein 5breast cancer-associated protein SGA-1Mputative MAPK-activating protein PM13putative NF-kappa-B-activating protein 164putative NFKB and MAPK-activating protein | serine/threonine-protein kinase SIK3salt-inducible kinase 3serine/threonine-protein kinase QSK | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9BT67 | Q9Y2K2 | |
| Ensembl transtripts involved in fusion gene | ENST00000253814, ENST00000509436, | ENST00000375300, ENST00000292055, ENST00000375288, ENST00000434315, ENST00000542607, ENST00000446921, ENST00000488337, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 6 X 6 X 3=108 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NDFIP1 [Title/Abstract] AND SIK3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NDFIP1 | GO:0031398 | positive regulation of protein ubiquitination | 25631046 |
| Tgene | SIK3 | GO:0006468 | protein phosphorylation | 14976552 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI743411 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000253814 | ENST00000375300 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| 3UTR-intron | ENST00000253814 | ENST00000292055 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| 3UTR-intron | ENST00000253814 | ENST00000375288 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| 3UTR-intron | ENST00000253814 | ENST00000434315 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| 3UTR-intron | ENST00000253814 | ENST00000542607 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| 3UTR-intron | ENST00000253814 | ENST00000446921 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| 3UTR-intron | ENST00000253814 | ENST00000488337 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| intron-intron | ENST00000509436 | ENST00000375300 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| intron-intron | ENST00000509436 | ENST00000292055 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| intron-intron | ENST00000509436 | ENST00000375288 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| intron-intron | ENST00000509436 | ENST00000434315 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| intron-intron | ENST00000509436 | ENST00000542607 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| intron-intron | ENST00000509436 | ENST00000446921 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
| intron-intron | ENST00000509436 | ENST00000488337 | NDFIP1 | chr5 | 141532059 | - | SIK3 | chr11 | 116967467 | + |
Top |
FusionProtFeatures for NDFIP1_SIK3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NDFIP1 | SIK3 |