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Fusion gene ID: 23726 |
FusionGeneSummary for NCOR1_UNC45B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCOR1_UNC45B | Fusion gene ID: 23726 | Hgene | Tgene | Gene symbol | NCOR1 | UNC45B | Gene ID | 9611 | 146862 |
| Gene name | nuclear receptor corepressor 1 | unc-45 myosin chaperone B | |
| Synonyms | N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR | CMYA4|CTRCT43|SMUNC45|UNC-45B|UNC45 | |
| Cytomap | 17p12-p11.2 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1 | protein unc-45 homolog Bcardiomyopathy associated 4striated muscle UNC45unc-45 homolog B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75376 | Q8IWX7 | |
| Ensembl transtripts involved in fusion gene | ENST00000268712, ENST00000395851, ENST00000395857, ENST00000395848, ENST00000583226, | ENST00000378449, ENST00000433649, ENST00000268876, ENST00000394570, ENST00000591048, | |
| Fusion gene scores | * DoF score | 18 X 14 X 10=2520 | 5 X 4 X 4=80 |
| # samples | 16 | 5 | |
| ** MAII score | log2(16/2520*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCOR1 [Title/Abstract] AND UNC45B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NCOR1 | GO:0046329 | negative regulation of JNK cascade | 11931768 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-FX-A3TO-01A | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000268712 | ENST00000378449 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000268712 | ENST00000433649 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000268712 | ENST00000268876 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000268712 | ENST00000394570 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000268712 | ENST00000591048 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395851 | ENST00000378449 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395851 | ENST00000433649 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395851 | ENST00000268876 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395851 | ENST00000394570 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395851 | ENST00000591048 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| intron-5UTR | ENST00000395857 | ENST00000378449 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| intron-5UTR | ENST00000395857 | ENST00000433649 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| intron-5UTR | ENST00000395857 | ENST00000268876 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| intron-5UTR | ENST00000395857 | ENST00000394570 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| intron-5UTR | ENST00000395857 | ENST00000591048 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395848 | ENST00000378449 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395848 | ENST00000433649 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395848 | ENST00000268876 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395848 | ENST00000394570 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5CDS-5UTR | ENST00000395848 | ENST00000591048 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5UTR-5UTR | ENST00000583226 | ENST00000378449 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5UTR-5UTR | ENST00000583226 | ENST00000433649 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5UTR-5UTR | ENST00000583226 | ENST00000268876 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5UTR-5UTR | ENST00000583226 | ENST00000394570 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
| 5UTR-5UTR | ENST00000583226 | ENST00000591048 | NCOR1 | chr17 | 16021202 | - | UNC45B | chr17 | 33475283 | + |
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FusionProtFeatures for NCOR1_UNC45B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCOR1 | UNC45B |