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Fusion gene ID: 23718

FusionGeneSummary for NCOR1_MPRIP

Fusion gene summary

Fusion gene information	Fusion gene name: NCOR1_MPRIP
	Fusion gene ID: 23718
		Hgene	Tgene
	Gene symbol	NCOR1	MPRIP
	Gene ID	9611	23164
	Gene name	nuclear receptor corepressor 1	myosin phosphatase Rho interacting protein
	Synonyms	N-CoR\|N-CoR1\|PPP1R109\|TRAC1\|hN-CoR	M-RIP\|MRIP\|RHOIP3\|RIP3\|p116Rip
	Cytomap	17p12-p11.2	17p11.2
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1	myosin phosphatase Rho-interacting proteinRho interacting protein 3
	Modification date	20180523	20180522
	UniProtAcc	O75376	Q6WCQ1
	Ensembl transtripts involved in fusion gene	ENST00000268712, ENST00000395851, ENST00000395857, ENST00000395848, ENST00000583226,	ENST00000395811, ENST00000444976, ENST00000395804, ENST00000341712, ENST00000395806, ENST00000395807,
Fusion gene scores	* DoF score	18 X 14 X 10=2520	4 X 3 X 4=48
	# samples	16	4
	** MAII score	log2(16/2520*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NCOR1 [Title/Abstract] AND MPRIP [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NCOR1	GO:0046329	negative regulation of JNK cascade	11931768

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	UCS	TCGA-N8-A4PQ-01A	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000268712	ENST00000395811	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
Frame-shift	ENST00000268712	ENST00000444976	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
Frame-shift	ENST00000268712	ENST00000395804	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
Frame-shift	ENST00000268712	ENST00000341712	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
5CDS-intron	ENST00000268712	ENST00000395806	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
5CDS-3UTR	ENST00000268712	ENST00000395807	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
In-frame	ENST00000395851	ENST00000395811	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
In-frame	ENST00000395851	ENST00000444976	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
In-frame	ENST00000395851	ENST00000395804	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
In-frame	ENST00000395851	ENST00000341712	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
5CDS-intron	ENST00000395851	ENST00000395806	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
5CDS-3UTR	ENST00000395851	ENST00000395807	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395857	ENST00000395811	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395857	ENST00000444976	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395857	ENST00000395804	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395857	ENST00000341712	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-intron	ENST00000395857	ENST00000395806	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3UTR	ENST00000395857	ENST00000395807	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395848	ENST00000395811	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395848	ENST00000444976	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395848	ENST00000395804	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000395848	ENST00000341712	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-intron	ENST00000395848	ENST00000395806	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3UTR	ENST00000395848	ENST00000395807	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000583226	ENST00000395811	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000583226	ENST00000444976	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000583226	ENST00000395804	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3CDS	ENST00000583226	ENST00000341712	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-intron	ENST00000583226	ENST00000395806	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+
intron-3UTR	ENST00000583226	ENST00000395807	NCOR1	chr17	16075117	-	MPRIP	chr17	16979024	+

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FusionProtFeatures for NCOR1_MPRIP

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NCOR1 O75376	MPRIP Q6WCQ1

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Fusion gene ID: 23718

FusionGeneSummary for NCOR1_MPRIP

FusionProtFeatures for NCOR1_MPRIP