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Fusion gene ID: 23692 |
FusionGeneSummary for NCOA5_CDH4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCOA5_CDH4 | Fusion gene ID: 23692 | Hgene | Tgene | Gene symbol | NCOA5 | CDH4 | Gene ID | 57727 | 1002 |
| Gene name | nuclear receptor coactivator 5 | cadherin 4 | |
| Synonyms | CIA|bA465L10.6 | CAD4|R-CAD|RCAD | |
| Cytomap | 20q13.12 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear receptor coactivator 5NCoA-5coactivator independent of AF-2 | cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HCD5 | P55283 | |
| Ensembl transtripts involved in fusion gene | ENST00000290231, | ENST00000360469, ENST00000543233, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 10 X 6 X 6=360 |
| # samples | 4 | 10 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCOA5 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A091-01A | NCOA5 | chr20 | 44708026 | - | CDH4 | chr20 | 60318619 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000290231 | ENST00000360469 | NCOA5 | chr20 | 44708026 | - | CDH4 | chr20 | 60318619 | + |
| 5CDS-5UTR | ENST00000290231 | ENST00000543233 | NCOA5 | chr20 | 44708026 | - | CDH4 | chr20 | 60318619 | + |
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FusionProtFeatures for NCOA5_CDH4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCOA5 | CDH4 |