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Fusion gene ID: 23624 |
FusionGeneSummary for NCL_FOXJ3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCL_FOXJ3 | Fusion gene ID: 23624 | Hgene | Tgene | Gene symbol | NCL | FOXJ3 | Gene ID | 80331 | 22887 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C5 | forkhead box J3 | |
| Synonyms | CLN4|CLN4B|CSP|DNAJC5A|NCL|mir-941-2|mir-941-3|mir-941-4|mir-941-5 | - | |
| Cytomap | 20q13.33 | 1p34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily C member 5DnaJ (Hsp40) homolog, subfamily C, member 5ceroid-lipofuscinosis neuronal protein 4cysteine string protein alpha | forkhead box protein J3 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | P19338 | Q9UPW0 | |
| Ensembl transtripts involved in fusion gene | ENST00000322723, | ENST00000372572, ENST00000372573, ENST00000361346, ENST00000361776, ENST00000545068, ENST00000372571, | |
| Fusion gene scores | * DoF score | 18 X 18 X 6=1944 | 9 X 8 X 3=216 |
| # samples | 22 | 8 | |
| ** MAII score | log2(22/1944*10)=-3.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NCL [Title/Abstract] AND FOXJ3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FOXJ3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22740631 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF877863 | NCL | chr2 | 232321787 | + | FOXJ3 | chr1 | 42684657 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000322723 | ENST00000372572 | NCL | chr2 | 232321787 | + | FOXJ3 | chr1 | 42684657 | - |
| intron-intron | ENST00000322723 | ENST00000372573 | NCL | chr2 | 232321787 | + | FOXJ3 | chr1 | 42684657 | - |
| intron-intron | ENST00000322723 | ENST00000361346 | NCL | chr2 | 232321787 | + | FOXJ3 | chr1 | 42684657 | - |
| intron-intron | ENST00000322723 | ENST00000361776 | NCL | chr2 | 232321787 | + | FOXJ3 | chr1 | 42684657 | - |
| intron-intron | ENST00000322723 | ENST00000545068 | NCL | chr2 | 232321787 | + | FOXJ3 | chr1 | 42684657 | - |
| intron-intron | ENST00000322723 | ENST00000372571 | NCL | chr2 | 232321787 | + | FOXJ3 | chr1 | 42684657 | - |
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FusionProtFeatures for NCL_FOXJ3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCL | FOXJ3 |