|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23572 |
FusionGeneSummary for NCBP2_PEX5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCBP2_PEX5 | Fusion gene ID: 23572 | Hgene | Tgene | Gene symbol | NCBP2 | PEX5 | Gene ID | 22916 | 5830 |
| Gene name | nuclear cap binding protein subunit 2 | peroxisomal biogenesis factor 5 | |
| Synonyms | CBC2|CBP20|NIP1|PIG55 | PBD2A|PBD2B|PTS1-BP|PTS1R|PXR1|RCDP5 | |
| Cytomap | 3q29 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear cap-binding protein subunit 220 kDa nuclear cap-binding proteinNCBP 20 kDa subunitNCBP interacting protein 1cell proliferation-inducing gene 55 proteinnuclear cap binding protein subunit 2, 20kDnuclear cap binding protein subunit 2, 20kDa | peroxisomal biogenesis factor 5PTS1 receptorperoxin-5peroxisomal C-terminal targeting signal import receptorperoxisomal import receptor 5peroxisomal targeting signal 1 (SKL type) receptorperoxisomal targeting signal 1 receptorperoxisomal targeting | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P52298 | P50542 | |
| Ensembl transtripts involved in fusion gene | ENST00000467803, ENST00000447325, ENST00000321256, ENST00000427641, ENST00000452404, ENST00000422610, | ENST00000455147, ENST00000266563, ENST00000545220, ENST00000434354, ENST00000420616, ENST00000412720, ENST00000266564, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NCBP2 [Title/Abstract] AND PEX5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NCBP2 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 11551508 |
| Hgene | NCBP2 | GO:0006446 | regulation of translational initiation | 11551508 |
| Hgene | NCBP2 | GO:0045292 | mRNA cis splicing, via spliceosome | 18426921 |
| Tgene | PEX5 | GO:0016560 | protein import into peroxisome matrix, docking | 21976670 |
| Tgene | PEX5 | GO:1901094 | negative regulation of protein homotetramerization | 21976670 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA625748 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000467803 | ENST00000455147 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000467803 | ENST00000266563 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000467803 | ENST00000545220 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000467803 | ENST00000434354 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000467803 | ENST00000420616 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000467803 | ENST00000412720 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000467803 | ENST00000266564 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000447325 | ENST00000455147 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000447325 | ENST00000266563 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000447325 | ENST00000545220 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000447325 | ENST00000434354 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000447325 | ENST00000420616 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000447325 | ENST00000412720 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000447325 | ENST00000266564 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000321256 | ENST00000455147 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000321256 | ENST00000266563 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000321256 | ENST00000545220 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000321256 | ENST00000434354 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000321256 | ENST00000420616 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000321256 | ENST00000412720 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000321256 | ENST00000266564 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000427641 | ENST00000455147 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000427641 | ENST00000266563 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000427641 | ENST00000545220 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000427641 | ENST00000434354 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000427641 | ENST00000420616 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000427641 | ENST00000412720 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000427641 | ENST00000266564 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000452404 | ENST00000455147 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000452404 | ENST00000266563 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000452404 | ENST00000545220 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000452404 | ENST00000434354 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000452404 | ENST00000420616 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000452404 | ENST00000412720 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000452404 | ENST00000266564 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000422610 | ENST00000455147 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000422610 | ENST00000266563 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000422610 | ENST00000545220 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000422610 | ENST00000434354 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000422610 | ENST00000420616 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000422610 | ENST00000412720 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
| intron-intron | ENST00000422610 | ENST00000266564 | NCBP2 | chr3 | 196662667 | + | PEX5 | chr12 | 7362434 | - |
Top |
FusionProtFeatures for NCBP2_PEX5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCBP2 | PEX5 |