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Fusion gene ID: 23559 |
FusionGeneSummary for NCAPD3_KBTBD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCAPD3_KBTBD3 | Fusion gene ID: 23559 | Hgene | Tgene | Gene symbol | NCAPD3 | KBTBD3 | Gene ID | 23310 | 143879 |
| Gene name | non-SMC condensin II complex subunit D3 | kelch repeat and BTB domain containing 3 | |
| Synonyms | CAP-D3|CAPD3|MCPH22|hCAP-D3|hHCP-6|hcp-6 | BKLHD3 | |
| Cytomap | 11q25 | 11q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | condensin-2 complex subunit D3 | kelch repeat and BTB domain-containing protein 3BTB and kelch domain containing 3BTB and kelch domain-containing protein 3kelch repeat and BTB (POZ) domain containing 3 | |
| Modification date | 20180525 | 20180523 | |
| UniProtAcc | P42695 | Q8NAB2 | |
| Ensembl transtripts involved in fusion gene | ENST00000534548, ENST00000526787, ENST00000526422, | ENST00000534815, ENST00000526793, ENST00000531837, ENST00000531482, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: NCAPD3 [Title/Abstract] AND KBTBD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NCAPD3 | GO:0007076 | mitotic chromosome condensation | 14532007 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-CF-A8HY-01A | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000534548 | ENST00000534815 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| 5CDS-5UTR | ENST00000534548 | ENST00000526793 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| 5CDS-5UTR | ENST00000534548 | ENST00000531837 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| 5CDS-5UTR | ENST00000534548 | ENST00000531482 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-intron | ENST00000526787 | ENST00000534815 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-5UTR | ENST00000526787 | ENST00000526793 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-5UTR | ENST00000526787 | ENST00000531837 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-5UTR | ENST00000526787 | ENST00000531482 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-intron | ENST00000526422 | ENST00000534815 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-5UTR | ENST00000526422 | ENST00000526793 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-5UTR | ENST00000526422 | ENST00000531837 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
| intron-5UTR | ENST00000526422 | ENST00000531482 | NCAPD3 | chr11 | 134062584 | - | KBTBD3 | chr11 | 105929836 | - |
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FusionProtFeatures for NCAPD3_KBTBD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCAPD3 | KBTBD3 |