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Fusion gene ID: 23490 |
FusionGeneSummary for NBAS_SPIRE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NBAS_SPIRE1 | Fusion gene ID: 23490 | Hgene | Tgene | Gene symbol | NBAS | SPIRE1 | Gene ID | 51594 | 56907 |
| Gene name | neuroblastoma amplified sequence | spire type actin nucleation factor 1 | |
| Synonyms | ILFS2|NAG|SOPH | Spir-1 | |
| Cytomap | 2p24.3 | 18p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein | protein spire homolog 1spire actin nucleation factor 1spire family actin nucleation factor 1spire homolog 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | A2RRP1 | Q08AE8 | |
| Ensembl transtripts involved in fusion gene | ENST00000441750, ENST00000281513, | ENST00000409402, ENST00000410092, ENST00000309836, ENST00000453447, ENST00000383356, ENST00000464481, | |
| Fusion gene scores | * DoF score | 11 X 10 X 7=770 | 3 X 3 X 2=18 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/770*10)=-2.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NBAS [Title/Abstract] AND SPIRE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-N8-A4PO-01A | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000441750 | ENST00000409402 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| intron-3CDS | ENST00000441750 | ENST00000410092 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| intron-3CDS | ENST00000441750 | ENST00000309836 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| intron-3CDS | ENST00000441750 | ENST00000453447 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| intron-3CDS | ENST00000441750 | ENST00000383356 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| intron-intron | ENST00000441750 | ENST00000464481 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| In-frame | ENST00000281513 | ENST00000409402 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| In-frame | ENST00000281513 | ENST00000410092 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| In-frame | ENST00000281513 | ENST00000309836 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| In-frame | ENST00000281513 | ENST00000453447 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| In-frame | ENST00000281513 | ENST00000383356 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
| 5CDS-intron | ENST00000281513 | ENST00000464481 | NBAS | chr2 | 15555670 | - | SPIRE1 | chr18 | 12512530 | - |
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FusionProtFeatures for NBAS_SPIRE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NBAS | SPIRE1 |