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Fusion gene ID: 23489 |
FusionGeneSummary for NBAS_RASGRP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NBAS_RASGRP3 | Fusion gene ID: 23489 | Hgene | Tgene | Gene symbol | NBAS | RASGRP3 | Gene ID | 51594 | 25780 |
| Gene name | neuroblastoma amplified sequence | RAS guanyl releasing protein 3 | |
| Synonyms | ILFS2|NAG|SOPH | GRP3 | |
| Cytomap | 2p24.3 | 2p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein | ras guanyl-releasing protein 3CalDAG-GEFIIIRAS guanyl releasing protein 3 (calcium and DAG-regulated)calcium and DAG-regulated guanine nucleotide exchange factor IIIcalcium- and diacylglycerol-regulated guanine nucleotide exchange factor IIIguanine n | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | A2RRP1 | Q8IV61 | |
| Ensembl transtripts involved in fusion gene | ENST00000441750, ENST00000281513, | ENST00000402538, ENST00000403687, ENST00000407811, ENST00000482731, | |
| Fusion gene scores | * DoF score | 11 X 10 X 7=770 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/770*10)=-2.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: NBAS [Title/Abstract] AND RASGRP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AX-A3G3-01A | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000441750 | ENST00000402538 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| Frame-shift | ENST00000441750 | ENST00000403687 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| Frame-shift | ENST00000441750 | ENST00000407811 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| 5CDS-intron | ENST00000441750 | ENST00000482731 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| In-frame | ENST00000281513 | ENST00000402538 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| Frame-shift | ENST00000281513 | ENST00000403687 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| Frame-shift | ENST00000281513 | ENST00000407811 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
| 5CDS-intron | ENST00000281513 | ENST00000482731 | NBAS | chr2 | 15415608 | - | RASGRP3 | chr2 | 33787796 | + |
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FusionProtFeatures for NBAS_RASGRP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NBAS | RASGRP3 |