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Fusion gene ID: 23486 |
FusionGeneSummary for NBAS_MLLT3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NBAS_MLLT3 | Fusion gene ID: 23486 | Hgene | Tgene | Gene symbol | NBAS | MLLT3 | Gene ID | 51594 | 4300 |
| Gene name | neuroblastoma amplified sequence | MLLT3, super elongation complex subunit | |
| Synonyms | ILFS2|NAG|SOPH | AF9|YEATS3 | |
| Cytomap | 2p24.3 | 9p21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma-amplified gene protein | protein AF-9ALL1-fused gene from chromosome 9 proteinYEATS domain-containing protein 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translo | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | A2RRP1 | P42568 | |
| Ensembl transtripts involved in fusion gene | ENST00000441750, ENST00000281513, | ENST00000380338, ENST00000355930, ENST00000429426, ENST00000475957, ENST00000380321, | |
| Fusion gene scores | * DoF score | 11 X 10 X 7=770 | 9 X 18 X 8=1296 |
| # samples | 12 | 22 | |
| ** MAII score | log2(12/770*10)=-2.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/1296*10)=-2.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NBAS [Title/Abstract] AND MLLT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MLLT3 | GO:0045893 | positive regulation of transcription, DNA-templated | 25417107|27105114 |
| Tgene | MLLT3 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 19591803 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | EF406122 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000441750 | ENST00000380338 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000441750 | ENST00000355930 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000441750 | ENST00000429426 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000441750 | ENST00000475957 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000441750 | ENST00000380321 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-3CDS | ENST00000281513 | ENST00000380338 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000281513 | ENST00000355930 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000281513 | ENST00000429426 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000281513 | ENST00000475957 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
| intron-5UTR | ENST00000281513 | ENST00000380321 | NBAS | chr2 | 14539776 | + | MLLT3 | chr9 | 20363607 | - |
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FusionProtFeatures for NBAS_MLLT3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NBAS | MLLT3 |