|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23407 |
FusionGeneSummary for NAPB_ZFP91 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NAPB_ZFP91 | Fusion gene ID: 23407 | Hgene | Tgene | Gene symbol | NAPB | ZFP91 | Gene ID | 63908 | 80829 |
| Gene name | NSF attachment protein beta | ZFP91 zinc finger protein | |
| Synonyms | SNAP-BETA|SNAPB | DMS-8|DSM-8|FKSG11|PZF|ZFP-91|ZNF757 | |
| Cytomap | 20p11.21 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-soluble NSF attachment proteinN-ethylmaleimide-sensitive factor attachment protein, beta | E3 ubiquitin-protein ligase ZFP91RING-type E3 ubiquitin transferase ZFP91drug resistance-associated sequence in melanoma 8penta zinc finger proteinzinc finger protein 757zinc finger protein 91 homologzinc finger protein homologous to Zfp91 in mouse | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H115 | Q96JP5 | |
| Ensembl transtripts involved in fusion gene | ENST00000377026, ENST00000398425, ENST00000432543, ENST00000472855, | ENST00000316059, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 6 X 6 X 2=72 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NAPB [Title/Abstract] AND ZFP91 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ZFP91 | GO:0007250 | activation of NF-kappaB-inducing kinase activity | 20682767 |
| Tgene | ZFP91 | GO:0070534 | protein K63-linked ubiquitination | 20682767 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ379630 | NAPB | chr20 | 23356493 | - | ZFP91 | chr11 | 58378490 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000377026 | ENST00000316059 | NAPB | chr20 | 23356493 | - | ZFP91 | chr11 | 58378490 | + |
| intron-3CDS | ENST00000398425 | ENST00000316059 | NAPB | chr20 | 23356493 | - | ZFP91 | chr11 | 58378490 | + |
| intron-3CDS | ENST00000432543 | ENST00000316059 | NAPB | chr20 | 23356493 | - | ZFP91 | chr11 | 58378490 | + |
| intron-3CDS | ENST00000472855 | ENST00000316059 | NAPB | chr20 | 23356493 | - | ZFP91 | chr11 | 58378490 | + |
Top |
FusionProtFeatures for NAPB_ZFP91 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NAPB | ZFP91 |