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Fusion gene ID: 23340 |
FusionGeneSummary for NACC2_LHX3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NACC2_LHX3 | Fusion gene ID: 23340 | Hgene | Tgene | Gene symbol | NACC2 | LHX3 | Gene ID | 138151 | 8022 |
| Gene name | NACC family member 2 | LIM homeobox 3 | |
| Synonyms | BEND9|BTBD14|BTBD14A|BTBD31|NAC-2|RBB | CPHD3|LIM3|M2-LHX3 | |
| Cytomap | 9q34.3 | 9q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nucleus accumbens-associated protein 2BEN domain containing 9BTB (POZ) domain containing 14ABTB/POZ domain-containing protein 14ANACC family member 2, BEN and BTB (POZ) domain containingrepressor with BTB domain and BEN domaintranscription repressor | LIM/homeobox protein Lhx3LIM homeobox protein 3LIM/homeodomain protein LHX3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96BF6 | Q9UBR4 | |
| Ensembl transtripts involved in fusion gene | ENST00000371753, ENST00000277554, ENST00000467669, | ENST00000371746, ENST00000371748, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 2 X 1 X 2=4 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: NACC2 [Title/Abstract] AND LHX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NACC2 | GO:0008285 | negative regulation of cell proliferation | 22926524 |
| Hgene | NACC2 | GO:0034629 | cellular protein-containing complex localization | 22926524 |
| Hgene | NACC2 | GO:0045892 | negative regulation of transcription, DNA-templated | 22926524 |
| Hgene | NACC2 | GO:0051260 | protein homooligomerization | 22926524 |
| Hgene | NACC2 | GO:1900477 | negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter | 22926524 |
| Hgene | NACC2 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 22926524 |
| Tgene | LHX3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15271874 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AX-A2H4-01A | NACC2 | chr9 | 138941482 | - | LHX3 | chr9 | 139092599 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000371753 | ENST00000371746 | NACC2 | chr9 | 138941482 | - | LHX3 | chr9 | 139092599 | - |
| Frame-shift | ENST00000371753 | ENST00000371748 | NACC2 | chr9 | 138941482 | - | LHX3 | chr9 | 139092599 | - |
| Frame-shift | ENST00000277554 | ENST00000371746 | NACC2 | chr9 | 138941482 | - | LHX3 | chr9 | 139092599 | - |
| Frame-shift | ENST00000277554 | ENST00000371748 | NACC2 | chr9 | 138941482 | - | LHX3 | chr9 | 139092599 | - |
| intron-3CDS | ENST00000467669 | ENST00000371746 | NACC2 | chr9 | 138941482 | - | LHX3 | chr9 | 139092599 | - |
| intron-3CDS | ENST00000467669 | ENST00000371748 | NACC2 | chr9 | 138941482 | - | LHX3 | chr9 | 139092599 | - |
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FusionProtFeatures for NACC2_LHX3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NACC2 | LHX3 |