|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 23318 |
FusionGeneSummary for NAALADL2_NCKAP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NAALADL2_NCKAP5 | Fusion gene ID: 23318 | Hgene | Tgene | Gene symbol | NAALADL2 | NCKAP5 | Gene ID | 254827 | 344148 |
| Gene name | N-acetylated alpha-linked acidic dipeptidase like 2 | NCK associated protein 5 | |
| Synonyms | - | ERIH1|ERIH2|NAP5 | |
| Cytomap | 3q26.31 | 2q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue | nck-associated protein 5NAP-5peripheral clock protein 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q58DX5 | O14513 | |
| Ensembl transtripts involved in fusion gene | ENST00000454872, ENST00000473253, | ENST00000409261, ENST00000409213, ENST00000405974, ENST00000317721, ENST00000473859, | |
| Fusion gene scores | * DoF score | 17 X 11 X 8=1496 | 9 X 8 X 4=288 |
| # samples | 17 | 9 | |
| ** MAII score | log2(17/1496*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NAALADL2 [Title/Abstract] AND NCKAP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-70-6722-01A | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000454872 | ENST00000409261 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| In-frame | ENST00000454872 | ENST00000409213 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| In-frame | ENST00000454872 | ENST00000405974 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| In-frame | ENST00000454872 | ENST00000317721 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| 5CDS-intron | ENST00000454872 | ENST00000473859 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| 3UTR-3CDS | ENST00000473253 | ENST00000409261 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| 3UTR-3CDS | ENST00000473253 | ENST00000409213 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| 3UTR-3CDS | ENST00000473253 | ENST00000405974 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| 3UTR-3CDS | ENST00000473253 | ENST00000317721 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
| 3UTR-intron | ENST00000473253 | ENST00000473859 | NAALADL2 | chr3 | 175189546 | + | NCKAP5 | chr2 | 133626547 | - |
Top |
FusionProtFeatures for NAALADL2_NCKAP5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NAALADL2 | NCKAP5 |