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Fusion gene ID: 23309 |
FusionGeneSummary for NAALADL2_ABCC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NAALADL2_ABCC5 | Fusion gene ID: 23309 | Hgene | Tgene | Gene symbol | NAALADL2 | ABCC5 | Gene ID | 254827 | 10057 |
| Gene name | N-acetylated alpha-linked acidic dipeptidase like 2 | ATP binding cassette subfamily C member 5 | |
| Synonyms | - | ABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11 | |
| Cytomap | 3q26.31 | 3q27.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue | multidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter C | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q58DX5 | O15440 | |
| Ensembl transtripts involved in fusion gene | ENST00000454872, ENST00000473253, | ENST00000334444, ENST00000265586, ENST00000492216, ENST00000427120, ENST00000392579, ENST00000382494, ENST00000446941, | |
| Fusion gene scores | * DoF score | 17 X 11 X 8=1496 | 6 X 7 X 6=252 |
| # samples | 17 | 7 | |
| ** MAII score | log2(17/1496*10)=-3.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NAALADL2 [Title/Abstract] AND ABCC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-33-4538-01A | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000454872 | ENST00000334444 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| In-frame | ENST00000454872 | ENST00000265586 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| 5CDS-intron | ENST00000454872 | ENST00000492216 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| 5CDS-intron | ENST00000454872 | ENST00000427120 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| 5CDS-intron | ENST00000454872 | ENST00000392579 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| 5CDS-intron | ENST00000454872 | ENST00000382494 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| 5CDS-intron | ENST00000454872 | ENST00000446941 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| intron-3CDS | ENST00000473253 | ENST00000334444 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| intron-3CDS | ENST00000473253 | ENST00000265586 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| intron-intron | ENST00000473253 | ENST00000492216 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| intron-intron | ENST00000473253 | ENST00000427120 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| intron-intron | ENST00000473253 | ENST00000392579 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| intron-intron | ENST00000473253 | ENST00000382494 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
| intron-intron | ENST00000473253 | ENST00000446941 | NAALADL2 | chr3 | 175345174 | + | ABCC5 | chr3 | 183643507 | - |
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FusionProtFeatures for NAALADL2_ABCC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NAALADL2 | ABCC5 |