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Fusion gene ID: 23248 |
FusionGeneSummary for MZT2B_IGFBP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MZT2B_IGFBP3 | Fusion gene ID: 23248 | Hgene | Tgene | Gene symbol | MZT2B | IGFBP3 | Gene ID | 80097 | 3486 |
| Gene name | mitotic spindle organizing protein 2B | insulin like growth factor binding protein 3 | |
| Synonyms | FAM128B|MOZART2B | BP-53|IBP3 | |
| Cytomap | 2q21.1 | 7p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitotic-spindle organizing protein 2Bfamily with sequence similarity 128, member Bmitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B | insulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding protein | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q6NZ67 | P17936 | |
| Ensembl transtripts involved in fusion gene | ENST00000281871, ENST00000409255, ENST00000491178, | ENST00000381086, ENST00000275521, ENST00000381083, ENST00000465642, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 1=25 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MZT2B [Title/Abstract] AND IGFBP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IGFBP3 | GO:0001933 | negative regulation of protein phosphorylation | 17591901 |
| Tgene | IGFBP3 | GO:0006468 | protein phosphorylation | 17434920 |
| Tgene | IGFBP3 | GO:0014912 | negative regulation of smooth muscle cell migration | 10766744 |
| Tgene | IGFBP3 | GO:0045663 | positive regulation of myoblast differentiation | 12599210 |
| Tgene | IGFBP3 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 10766744 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU753901 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000281871 | ENST00000381086 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| 5CDS-intron | ENST00000281871 | ENST00000275521 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| 5CDS-intron | ENST00000281871 | ENST00000381083 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| 5CDS-intron | ENST00000281871 | ENST00000465642 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| 5CDS-intron | ENST00000409255 | ENST00000381086 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| 5CDS-intron | ENST00000409255 | ENST00000275521 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| 5CDS-intron | ENST00000409255 | ENST00000381083 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| 5CDS-intron | ENST00000409255 | ENST00000465642 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| intron-intron | ENST00000491178 | ENST00000381086 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| intron-intron | ENST00000491178 | ENST00000275521 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| intron-intron | ENST00000491178 | ENST00000381083 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
| intron-intron | ENST00000491178 | ENST00000465642 | MZT2B | chr2 | 130948058 | - | IGFBP3 | chr7 | 45960457 | + |
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FusionProtFeatures for MZT2B_IGFBP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MZT2B | IGFBP3 |