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Fusion gene ID: 23189 |
FusionGeneSummary for MYO7A_MYO7A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYO7A_MYO7A | Fusion gene ID: 23189 | Hgene | Tgene | Gene symbol | MYO7A | MYO7A | Gene ID | 4647 | 4647 |
| Gene name | myosin VIIA | myosin VIIA | |
| Synonyms | DFNA11|DFNB2|MYOVIIA|MYU7A|NSRD2|USH1B | DFNA11|DFNB2|MYOVIIA|MYU7A|NSRD2|USH1B | |
| Cytomap | 11q13.5 | 11q13.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional myosin-VIIamyosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) | unconventional myosin-VIIamyosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q13402 | Q13402 | |
| Ensembl transtripts involved in fusion gene | ENST00000409709, ENST00000409893, ENST00000458637, ENST00000409619, ENST00000605744, | ENST00000409709, ENST00000409893, ENST00000458637, ENST00000409619, ENST00000605744, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 7 X 4=252 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYO7A [Title/Abstract] AND MYO7A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYO7A | GO:0007040 | lysosome organization | 16001398 |
| Hgene | MYO7A | GO:0030048 | actin filament-based movement | 21687988 |
| Tgene | MYO7A | GO:0007040 | lysosome organization | 16001398 |
| Tgene | MYO7A | GO:0030048 | actin filament-based movement | 21687988 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI050206 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000409709 | ENST00000409709 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000409709 | ENST00000409893 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000409709 | ENST00000458637 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000409709 | ENST00000409619 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-3UTR | ENST00000409709 | ENST00000605744 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| intron-3CDS | ENST00000409893 | ENST00000409709 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| intron-intron | ENST00000409893 | ENST00000409893 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| intron-intron | ENST00000409893 | ENST00000458637 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| intron-intron | ENST00000409893 | ENST00000409619 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| intron-3UTR | ENST00000409893 | ENST00000605744 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| In-frame | ENST00000458637 | ENST00000409709 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000458637 | ENST00000409893 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000458637 | ENST00000458637 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000458637 | ENST00000409619 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-3UTR | ENST00000458637 | ENST00000605744 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| In-frame | ENST00000409619 | ENST00000409709 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000409619 | ENST00000409893 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000409619 | ENST00000458637 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-intron | ENST00000409619 | ENST00000409619 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 5CDS-3UTR | ENST00000409619 | ENST00000605744 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 3UTR-3CDS | ENST00000605744 | ENST00000409709 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 3UTR-intron | ENST00000605744 | ENST00000409893 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 3UTR-intron | ENST00000605744 | ENST00000458637 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 3UTR-intron | ENST00000605744 | ENST00000409619 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
| 3UTR-3UTR | ENST00000605744 | ENST00000605744 | MYO7A | chr11 | 76918377 | - | MYO7A | chr11 | 76922267 | + |
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FusionProtFeatures for MYO7A_MYO7A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYO7A | MYO7A |