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Fusion gene ID: 23175

FusionGeneSummary for MYO5B_PPP1R8

Fusion gene summary

Fusion gene information	Fusion gene name: MYO5B_PPP1R8
	Fusion gene ID: 23175
		Hgene	Tgene
	Gene symbol	MYO5B	PPP1R8
	Gene ID	4645	5511
	Gene name	myosin VB	protein phosphatase 1 regulatory subunit 8
	Synonyms	-	ARD-1\|ARD1\|NIPP-1\|NIPP1\|PRO2047
	Cytomap	18q21.1	1p35.3
	Type of gene	protein-coding	protein-coding
	Description	unconventional myosin-VbMYO5B variant proteinmyosin-Vb	nuclear inhibitor of protein phosphatase 1RNase Eactivator of RNA decaynuclear inhibitor of protein phosphatase-1 alphanuclear inhibitor of protein phosphatase-1 betanuclear subunit of PP-1protein phosphatase 1, regulatory (inhibitor) subunit 8
	Modification date	20180519	20180523
	UniProtAcc	Q9ULV0	Q12972
	Ensembl transtripts involved in fusion gene	ENST00000285039, ENST00000324581, ENST00000592688, ENST00000587895,	ENST00000311772, ENST00000236412, ENST00000373931, ENST00000486634,
Fusion gene scores	* DoF score	8 X 4 X 6=192	2 X 2 X 1=4
	# samples	8	2
	** MAII score	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: MYO5B [Title/Abstract] AND PPP1R8 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			M78404	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000285039	ENST00000311772	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000285039	ENST00000236412	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000285039	ENST00000373931	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000285039	ENST00000486634	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000324581	ENST00000311772	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000324581	ENST00000236412	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000324581	ENST00000373931	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000324581	ENST00000486634	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000592688	ENST00000311772	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000592688	ENST00000236412	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000592688	ENST00000373931	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000592688	ENST00000486634	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000587895	ENST00000311772	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000587895	ENST00000236412	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000587895	ENST00000373931	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+
intron-intron	ENST00000587895	ENST00000486634	MYO5B	chr18	47587355	+	PPP1R8	chr1	28158085	+

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FusionProtFeatures for MYO5B_PPP1R8

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MYO5B Q9ULV0	PPP1R8 Q12972

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Fusion gene ID: 23175

FusionGeneSummary for MYO5B_PPP1R8

FusionProtFeatures for MYO5B_PPP1R8