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Fusion gene ID: 23168 |
FusionGeneSummary for MYO5B_CCDC11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYO5B_CCDC11 | Fusion gene ID: 23168 | Hgene | Tgene | Gene symbol | MYO5B | CCDC11 | Gene ID | 4645 | 220136 |
| Gene name | myosin VB | cilia and flagella associated protein 53 | |
| Synonyms | - | CCDC11|HTX6 | |
| Cytomap | 18q21.1 | 18q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional myosin-VbMYO5B variant proteinmyosin-Vb | cilia- and flagella-associated protein 53coiled-coil domain containing 11 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9ULV0 | ||
| Ensembl transtripts involved in fusion gene | ENST00000285039, ENST00000324581, ENST00000592688, ENST00000587895, | ENST00000398545, | |
| Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MYO5B [Title/Abstract] AND CCDC11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-GV-A3JZ-01A | MYO5B | chr18 | 47721137 | - | CCDC11 | chr18 | 47788589 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000285039 | ENST00000398545 | MYO5B | chr18 | 47721137 | - | CCDC11 | chr18 | 47788589 | - |
| intron-3CDS | ENST00000324581 | ENST00000398545 | MYO5B | chr18 | 47721137 | - | CCDC11 | chr18 | 47788589 | - |
| intron-3CDS | ENST00000592688 | ENST00000398545 | MYO5B | chr18 | 47721137 | - | CCDC11 | chr18 | 47788589 | - |
| intron-3CDS | ENST00000587895 | ENST00000398545 | MYO5B | chr18 | 47721137 | - | CCDC11 | chr18 | 47788589 | - |
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FusionProtFeatures for MYO5B_CCDC11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYO5B | CCDC11 |