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Fusion gene ID: 2312 |
FusionGeneSummary for AREL1_SYNDIG1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AREL1_SYNDIG1L | Fusion gene ID: 2312 | Hgene | Tgene | Gene symbol | AREL1 | SYNDIG1L | Gene ID | 9870 | 646658 |
| Gene name | apoptosis resistant E3 ubiquitin protein ligase 1 | synapse differentiation inducing 1 like | |
| Synonyms | FIEL1|KIAA0317 | CAPUCIN|DSPC1|IFITMD4|TMEM90A | |
| Cytomap | 14q24.3 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apoptosis-resistant E3 ubiquitin protein ligase 1apoptosis-resistant HECT-type E3 ubiquitin transferase 1fibrosis-inducing E3 ligase 1 | synapse differentiation-inducing gene protein 1-likecaudate- and putamen-enriched sequencedispanin subfamily C member 1interferon induced transmembrane protein domain containing 4transmembrane protein 90A | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | O15033 | A6NDD5 | |
| Ensembl transtripts involved in fusion gene | ENST00000557401, ENST00000356357, | ENST00000331628, ENST00000554823, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: AREL1 [Title/Abstract] AND SYNDIG1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AREL1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 23479728 |
| Hgene | AREL1 | GO:0043066 | negative regulation of apoptotic process | 23479728 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-20-0987-01A | AREL1 | chr14 | 75151157 | - | SYNDIG1L | chr14 | 74876504 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000557401 | ENST00000331628 | AREL1 | chr14 | 75151157 | - | SYNDIG1L | chr14 | 74876504 | - |
| 5UTR-5UTR | ENST00000557401 | ENST00000554823 | AREL1 | chr14 | 75151157 | - | SYNDIG1L | chr14 | 74876504 | - |
| 5CDS-5UTR | ENST00000356357 | ENST00000331628 | AREL1 | chr14 | 75151157 | - | SYNDIG1L | chr14 | 74876504 | - |
| 5CDS-5UTR | ENST00000356357 | ENST00000554823 | AREL1 | chr14 | 75151157 | - | SYNDIG1L | chr14 | 74876504 | - |
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FusionProtFeatures for AREL1_SYNDIG1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AREL1 | SYNDIG1L |