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Fusion gene ID: 23087 |
FusionGeneSummary for MYO10_SETX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYO10_SETX | Fusion gene ID: 23087 | Hgene | Tgene | Gene symbol | MYO10 | SETX | Gene ID | 4651 | 23064 |
| Gene name | myosin X | senataxin | |
| Synonyms | - | ALS4|AOA2|SCAR1|Sen1|bA479K20.2 | |
| Cytomap | 5p15.1 | 9q34.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | unconventional myosin-Xunconventional myosin-10unconventionnal myosin-X | probable helicase senataxinSEN1 homologamyotrophic lateral sclerosis 4 protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HD67 | Q7Z333 | |
| Ensembl transtripts involved in fusion gene | ENST00000513610, ENST00000507288, ENST00000274203, ENST00000515803, ENST00000427430, ENST00000505695, ENST00000512061, | ENST00000477049, ENST00000224140, ENST00000393220, ENST00000372169, | |
| Fusion gene scores | * DoF score | 13 X 10 X 6=780 | 3 X 3 X 1=9 |
| # samples | 15 | 3 | |
| ** MAII score | log2(15/780*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MYO10 [Title/Abstract] AND SETX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SETX | GO:0000165 | MAPK cascade | 21576111 |
| Tgene | SETX | GO:0006302 | double-strand break repair | 17562789 |
| Tgene | SETX | GO:0006974 | cellular response to DNA damage stimulus | 17562789 |
| Tgene | SETX | GO:0008543 | fibroblast growth factor receptor signaling pathway | 21576111 |
| Tgene | SETX | GO:0010976 | positive regulation of neuron projection development | 21576111 |
| Tgene | SETX | GO:0034599 | cellular response to oxidative stress | 17562789 |
| Tgene | SETX | GO:0043066 | negative regulation of apoptotic process | 21576111 |
| Tgene | SETX | GO:0043491 | protein kinase B signaling | 21576111 |
| Tgene | SETX | GO:0044344 | cellular response to fibroblast growth factor stimulus | 21576111 |
| Tgene | SETX | GO:0070301 | cellular response to hydrogen peroxide | 17562789 |
| Tgene | SETX | GO:0071300 | cellular response to retinoic acid | 21576111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | H83516 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000513610 | ENST00000477049 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000513610 | ENST00000224140 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000513610 | ENST00000393220 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000513610 | ENST00000372169 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-5UTR | ENST00000507288 | ENST00000477049 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000507288 | ENST00000224140 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000507288 | ENST00000393220 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000507288 | ENST00000372169 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-5UTR | ENST00000274203 | ENST00000477049 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000274203 | ENST00000224140 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000274203 | ENST00000393220 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000274203 | ENST00000372169 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-5UTR | ENST00000515803 | ENST00000477049 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000515803 | ENST00000224140 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000515803 | ENST00000393220 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000515803 | ENST00000372169 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-5UTR | ENST00000427430 | ENST00000477049 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000427430 | ENST00000224140 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000427430 | ENST00000393220 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000427430 | ENST00000372169 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-5UTR | ENST00000505695 | ENST00000477049 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000505695 | ENST00000224140 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000505695 | ENST00000393220 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000505695 | ENST00000372169 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-5UTR | ENST00000512061 | ENST00000477049 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000512061 | ENST00000224140 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000512061 | ENST00000393220 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
| intron-3UTR | ENST00000512061 | ENST00000372169 | MYO10 | chr5 | 16818142 | - | SETX | chr9 | 135137588 | - |
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FusionProtFeatures for MYO10_SETX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYO10 | SETX |