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Fusion gene ID: 23011 |
FusionGeneSummary for MYH9_JUP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYH9_JUP | Fusion gene ID: 23011 | Hgene | Tgene | Gene symbol | MYH9 | JUP | Gene ID | 4627 | 3728 |
| Gene name | myosin heavy chain 9 | junction plakoglobin | |
| Synonyms | BDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA | CTNNG|DP3|DPIII|PDGB|PKGB | |
| Cytomap | 22q12.3 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-A | junction plakoglobincatenin (cadherin-associated protein), gamma 80kDadesmoplakin IIIdesmoplakin-3 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P35579 | P14923 | |
| Ensembl transtripts involved in fusion gene | ENST00000216181, ENST00000475726, ENST00000401701, | ENST00000540235, ENST00000393930, ENST00000393931, ENST00000310706, | |
| Fusion gene scores | * DoF score | 36 X 33 X 15=17820 | 21 X 22 X 8=3696 |
| # samples | 50 | 29 | |
| ** MAII score | log2(50/17820*10)=-5.1554254317472 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(29/3696*10)=-3.67183995140112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYH9 [Title/Abstract] AND JUP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYH9 | GO:0001525 | angiogenesis | 16403913 |
| Hgene | MYH9 | GO:0006509 | membrane protein ectodomain proteolysis | 16186248 |
| Hgene | MYH9 | GO:0030048 | actin filament-based movement | 12237319|15845534 |
| Hgene | MYH9 | GO:0031032 | actomyosin structure organization | 24072716 |
| Tgene | JUP | GO:0002159 | desmosome assembly | 22889254 |
| Tgene | JUP | GO:0042127 | regulation of cell proliferation | 17924338 |
| Tgene | JUP | GO:0042307 | positive regulation of protein import into nucleus | 10825188|14661054 |
| Tgene | JUP | GO:0050982 | detection of mechanical stimulus | 18937352 |
| Tgene | JUP | GO:0051091 | positive regulation of DNA binding transcription factor activity | 14661054 |
| Tgene | JUP | GO:0071681 | cellular response to indole-3-methanol | 10868478 |
| Tgene | JUP | GO:0098609 | cell-cell adhesion | 18937352 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE185392 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000216181 | ENST00000540235 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000216181 | ENST00000393930 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000216181 | ENST00000393931 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000216181 | ENST00000310706 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000475726 | ENST00000540235 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000475726 | ENST00000393930 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000475726 | ENST00000393931 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000475726 | ENST00000310706 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000401701 | ENST00000540235 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000401701 | ENST00000393930 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000401701 | ENST00000393931 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
| intron-intron | ENST00000401701 | ENST00000310706 | MYH9 | chr22 | 36696928 | - | JUP | chr17 | 39846352 | - |
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FusionProtFeatures for MYH9_JUP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYH9 | JUP |