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Fusion gene ID: 22976 |
FusionGeneSummary for MYH11_RAB2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYH11_RAB2A | Fusion gene ID: 22976 | Hgene | Tgene | Gene symbol | MYH11 | RAB2A | Gene ID | 4629 | 5862 |
| Gene name | myosin heavy chain 11 | RAB2A, member RAS oncogene family | |
| Synonyms | AAT4|FAA4|SMHC|SMMHC | LHX|RAB2 | |
| Cytomap | 16p13.11 | 8q12.1-q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin-11myosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle | ras-related protein Rab-2ARAB2, member RAS oncogene familysmall GTP binding protein RAB2A | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P35749 | P61019 | |
| Ensembl transtripts involved in fusion gene | ENST00000396324, ENST00000452625, ENST00000576790, ENST00000300036, ENST00000573908, | ENST00000262646, ENST00000531289, ENST00000529579, ENST00000530071, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 7 X 6 X 4=168 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYH11 [Title/Abstract] AND RAB2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW377018 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000396324 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000396324 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000396324 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000396324 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000452625 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000452625 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000452625 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000452625 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000576790 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000576790 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000576790 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000576790 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000300036 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000300036 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000300036 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000300036 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000573908 | ENST00000262646 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000573908 | ENST00000531289 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000573908 | ENST00000529579 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
| intron-intron | ENST00000573908 | ENST00000530071 | MYH11 | chr16 | 15835653 | - | RAB2A | chr8 | 61518931 | - |
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FusionProtFeatures for MYH11_RAB2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYH11 | RAB2A |