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Fusion gene ID: 22972 |
FusionGeneSummary for MYH10_OLFM4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYH10_OLFM4 | Fusion gene ID: 22972 | Hgene | Tgene | Gene symbol | MYH10 | OLFM4 | Gene ID | 4628 | 10562 |
| Gene name | myosin heavy chain 10 | olfactomedin 4 | |
| Synonyms | NMMHC-IIB|NMMHCB | GC1|GW112|OLM4|OlfD|UNQ362|bA209J19.1|hGC-1|hOLfD | |
| Cytomap | 17p13.1 | 13q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin-10cellular myosin heavy chain, type Bmyosin heavy chain, nonmuscle type Bmyosin, heavy chain 10, non-musclemyosin, heavy polypeptide 10, non-musclenonmuscle myosin II heavy chain-Bnonmuscle myosin heavy chain IIB | olfactomedin-4G-CSF-stimulated clone 1 proteinantiapoptotic protein GW112 | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | P35580 | Q6UX06 | |
| Ensembl transtripts involved in fusion gene | ENST00000360416, ENST00000379980, ENST00000396239, ENST00000269243, | ENST00000219022, | |
| Fusion gene scores | * DoF score | 8 X 8 X 4=256 | 3 X 3 X 2=18 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/256*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MYH10 [Title/Abstract] AND OLFM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYH10 | GO:0000281 | mitotic cytokinesis | 15774463 |
| Hgene | MYH10 | GO:0030048 | actin filament-based movement | 15845534 |
| Tgene | OLFM4 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 16566923 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-X6-A8C5-01A | MYH10 | chr17 | 8533972 | - | OLFM4 | chr13 | 53608483 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000360416 | ENST00000219022 | MYH10 | chr17 | 8533972 | - | OLFM4 | chr13 | 53608483 | + |
| 5UTR-3CDS | ENST00000379980 | ENST00000219022 | MYH10 | chr17 | 8533972 | - | OLFM4 | chr13 | 53608483 | + |
| 5UTR-3CDS | ENST00000396239 | ENST00000219022 | MYH10 | chr17 | 8533972 | - | OLFM4 | chr13 | 53608483 | + |
| 5UTR-3CDS | ENST00000269243 | ENST00000219022 | MYH10 | chr17 | 8533972 | - | OLFM4 | chr13 | 53608483 | + |
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FusionProtFeatures for MYH10_OLFM4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYH10 | OLFM4 |