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Fusion gene ID: 22964 |
FusionGeneSummary for MYD88_ARHGEF10L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYD88_ARHGEF10L | Fusion gene ID: 22964 | Hgene | Tgene | Gene symbol | MYD88 | ARHGEF10L | Gene ID | 4615 | 55160 |
| Gene name | myeloid differentiation primary response 88 | Rho guanine nucleotide exchange factor 10 like | |
| Synonyms | MYD88D | GrinchGEF | |
| Cytomap | 3p22.2 | 1p36.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myeloid differentiation primary response protein MyD88mutant myeloid differentiation primary response 88myeloid differentiation primary response gene (88) | rho guanine nucleotide exchange factor 10-like proteinRho guanine nucleotide exchange factor (GEF) 10-like | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | Q99836 | Q9HCE6 | |
| Ensembl transtripts involved in fusion gene | ENST00000417037, ENST00000396334, ENST00000424893, ENST00000495303, ENST00000443433, ENST00000481122, | ENST00000434513, ENST00000361221, ENST00000452522, ENST00000375415, ENST00000375420, ENST00000469726, ENST00000375408, ENST00000167825, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 8 X 8 X 3=192 |
| # samples | 5 | 10 | |
| ** MAII score | log2(5/9*10)=2.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/192*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYD88 [Title/Abstract] AND ARHGEF10L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYD88 | GO:0070935 | 3'-UTR-mediated mRNA stabilization | 15294994 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE161378 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - | ||
| ChiTaRS3.1 | BE161373 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000417037 | ENST00000434513 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000417037 | ENST00000361221 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000417037 | ENST00000452522 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000417037 | ENST00000375415 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000417037 | ENST00000375420 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000417037 | ENST00000469726 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000417037 | ENST00000375408 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000417037 | ENST00000167825 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000396334 | ENST00000434513 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000396334 | ENST00000361221 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000396334 | ENST00000452522 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000396334 | ENST00000375415 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000396334 | ENST00000375420 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000396334 | ENST00000469726 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000396334 | ENST00000375408 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000396334 | ENST00000167825 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000424893 | ENST00000434513 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000424893 | ENST00000361221 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000424893 | ENST00000452522 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000424893 | ENST00000375415 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000424893 | ENST00000375420 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000424893 | ENST00000469726 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000424893 | ENST00000375408 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000424893 | ENST00000167825 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000495303 | ENST00000434513 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000495303 | ENST00000361221 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000495303 | ENST00000452522 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000495303 | ENST00000375415 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000495303 | ENST00000375420 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000495303 | ENST00000469726 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000495303 | ENST00000375408 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000495303 | ENST00000167825 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000443433 | ENST00000434513 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000443433 | ENST00000361221 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000443433 | ENST00000452522 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000443433 | ENST00000375415 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-intron | ENST00000443433 | ENST00000375420 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000443433 | ENST00000469726 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000443433 | ENST00000375408 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| 3UTR-3UTR | ENST00000443433 | ENST00000167825 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-intron | ENST00000481122 | ENST00000434513 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-intron | ENST00000481122 | ENST00000361221 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-intron | ENST00000481122 | ENST00000452522 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-intron | ENST00000481122 | ENST00000375415 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-intron | ENST00000481122 | ENST00000375420 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-3UTR | ENST00000481122 | ENST00000469726 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-3UTR | ENST00000481122 | ENST00000375408 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
| intron-3UTR | ENST00000481122 | ENST00000167825 | MYD88 | chr3 | 38182836 | - | ARHGEF10L | chr1 | 18021736 | - |
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FusionProtFeatures for MYD88_ARHGEF10L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYD88 | ARHGEF10L |