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Fusion gene ID: 22953 |
FusionGeneSummary for MYCBP2_ATG7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYCBP2_ATG7 | Fusion gene ID: 22953 | Hgene | Tgene | Gene symbol | MYCBP2 | ATG7 | Gene ID | 23077 | 10533 |
| Gene name | MYC binding protein 2, E3 ubiquitin protein ligase | autophagy related 7 | |
| Synonyms | Myc-bp2|PAM|Phr | APG7-LIKE|APG7L|GSA7 | |
| Cytomap | 13q22.3 | 3p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase MYCBP2HighwireRING-type E3 ubiquitin transferase MYCBP2myc-binding protein 2pam/highwire/rpm-1 proteinprotein associated with Myc | ubiquitin-like modifier-activating enzyme ATG7APG7 autophagy 7-likeATG12-activating enzyme E1 ATG7hAGP7ubiquitin-activating enzyme E1-like protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75592 | O95352 | |
| Ensembl transtripts involved in fusion gene | ENST00000544440, ENST00000407578, ENST00000357337, ENST00000360084, ENST00000482517, | ENST00000446450, ENST00000354956, ENST00000354449, ENST00000469654, | |
| Fusion gene scores | * DoF score | 9 X 9 X 7=567 | 11 X 11 X 7=847 |
| # samples | 9 | 15 | |
| ** MAII score | log2(9/567*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/847*10)=-2.49739946883632 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYCBP2 [Title/Abstract] AND ATG7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATG7 | GO:0006497 | protein lipidation | 12890687 |
| Tgene | ATG7 | GO:0009267 | cellular response to starvation | 20543840 |
| Tgene | ATG7 | GO:0031401 | positive regulation of protein modification process | 12890687 |
| Tgene | ATG7 | GO:0071455 | cellular response to hyperoxia | 20543840 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF931523 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000544440 | ENST00000446450 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000544440 | ENST00000354956 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000544440 | ENST00000354449 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000544440 | ENST00000469654 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000407578 | ENST00000446450 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000407578 | ENST00000354956 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000407578 | ENST00000354449 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000407578 | ENST00000469654 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000357337 | ENST00000446450 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000357337 | ENST00000354956 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000357337 | ENST00000354449 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000357337 | ENST00000469654 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000360084 | ENST00000446450 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000360084 | ENST00000354956 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000360084 | ENST00000354449 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000360084 | ENST00000469654 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000482517 | ENST00000446450 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000482517 | ENST00000354956 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000482517 | ENST00000354449 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
| intron-intron | ENST00000482517 | ENST00000469654 | MYCBP2 | chr13 | 77651362 | - | ATG7 | chr3 | 11599200 | - |
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FusionProtFeatures for MYCBP2_ATG7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYCBP2 | ATG7 |