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Fusion gene ID: 22933 |
FusionGeneSummary for MYADM_SPIDR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MYADM_SPIDR | Fusion gene ID: 22933 | Hgene | Tgene | Gene symbol | MYADM | SPIDR | Gene ID | 91663 | 23514 |
| Gene name | myeloid associated differentiation marker | scaffold protein involved in DNA repair | |
| Synonyms | SB135 | KIAA0146 | |
| Cytomap | 19q13.42 | 8q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myeloid-associated differentiation markermyeloid upregulated protein | DNA repair-scaffolding proteinscaffolding protein involved in DNA repair | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96S97 | Q14159 | |
| Ensembl transtripts involved in fusion gene | ENST00000336967, ENST00000391771, ENST00000391770, ENST00000391769, ENST00000391768, | ENST00000297423, ENST00000518074, ENST00000541342, ENST00000521214, ENST00000517693, ENST00000518060, | |
| Fusion gene scores | * DoF score | 1 X 2 X 1=2 | 12 X 13 X 8=1248 |
| # samples | 2 | 18 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(18/1248*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MYADM [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MYADM | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 23264465 |
| Tgene | SPIDR | GO:0006974 | cellular response to DNA damage stimulus | 23509288 |
| Tgene | SPIDR | GO:0010569 | regulation of double-strand break repair via homologous recombination | 23754376 |
| Tgene | SPIDR | GO:0031334 | positive regulation of protein complex assembly | 23509288 |
| Tgene | SPIDR | GO:0070202 | regulation of establishment of protein localization to chromosome | 23509288 |
| Tgene | SPIDR | GO:0071479 | cellular response to ionizing radiation | 23509288|23754376 |
| Tgene | SPIDR | GO:0072711 | cellular response to hydroxyurea | 23509288 |
| Tgene | SPIDR | GO:0072757 | cellular response to camptothecin | 23509288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI021868 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - | ||
| ChiTaRS3.1 | BI024730 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000336967 | ENST00000297423 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000336967 | ENST00000518074 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000336967 | ENST00000541342 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000336967 | ENST00000521214 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000336967 | ENST00000517693 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000336967 | ENST00000518060 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391771 | ENST00000297423 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391771 | ENST00000518074 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391771 | ENST00000541342 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391771 | ENST00000521214 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391771 | ENST00000517693 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391771 | ENST00000518060 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391770 | ENST00000297423 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391770 | ENST00000518074 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391770 | ENST00000541342 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391770 | ENST00000521214 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391770 | ENST00000517693 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391770 | ENST00000518060 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391769 | ENST00000297423 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391769 | ENST00000518074 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391769 | ENST00000541342 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391769 | ENST00000521214 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391769 | ENST00000517693 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391769 | ENST00000518060 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391768 | ENST00000297423 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391768 | ENST00000518074 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391768 | ENST00000541342 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391768 | ENST00000521214 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391768 | ENST00000517693 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391768 | ENST00000518060 | MYADM | chr19 | 54377456 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000336967 | ENST00000297423 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000336967 | ENST00000518074 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000336967 | ENST00000541342 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000336967 | ENST00000521214 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000336967 | ENST00000517693 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000336967 | ENST00000518060 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391771 | ENST00000297423 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391771 | ENST00000518074 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391771 | ENST00000541342 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391771 | ENST00000521214 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391771 | ENST00000517693 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391771 | ENST00000518060 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391770 | ENST00000297423 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391770 | ENST00000518074 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391770 | ENST00000541342 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391770 | ENST00000521214 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391770 | ENST00000517693 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391770 | ENST00000518060 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391769 | ENST00000297423 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391769 | ENST00000518074 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391769 | ENST00000541342 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391769 | ENST00000521214 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391769 | ENST00000517693 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391769 | ENST00000518060 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391768 | ENST00000297423 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391768 | ENST00000518074 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| Frame-shift | ENST00000391768 | ENST00000541342 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-3UTR | ENST00000391768 | ENST00000521214 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391768 | ENST00000517693 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
| 5CDS-intron | ENST00000391768 | ENST00000518060 | MYADM | chr19 | 54377459 | + | SPIDR | chr8 | 48511721 | - |
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FusionProtFeatures for MYADM_SPIDR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MYADM | SPIDR |