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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2292

FusionGeneSummary for ARAP1_DYNC2H1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARAP1_DYNC2H1
Fusion gene ID: 2292
HgeneTgene
Gene symbol

ARAP1

DYNC2H1

Gene ID

116985

79659

Gene nameArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1dynein cytoplasmic 2 heavy chain 1
SynonymsCENTD2ATD3|DHC1b|DHC2|DNCH2|DYH1B|SRPS2B|SRTD3|hdhc11
Cytomap

11q13.4

11q22.3

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1centaurin-delta-2cnt-d2cytoplasmic dynein 2 heavy chain 1dynein cytoplasmic heavy chain 2dynein heavy chain 11dynein heavy chain, isotype 1Bdynein, cytoplasmic, heavy polypeptide 2
Modification date2018052320180523
UniProtAcc

Q96P48

Q8NCM8

Ensembl transtripts involved in fusion geneENST00000359373, ENST00000495878, 
ENST00000455638, ENST00000393605, 
ENST00000334211, ENST00000393609, 
ENST00000426523, ENST00000429686, 
ENST00000375735, ENST00000334267, 
ENST00000398093, 
Fusion gene scores* DoF score11 X 11 X 9=10899 X 8 X 7=504
# samples 1110
** MAII scorelog2(11/1089*10)=-3.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARAP1 [Title/Abstract] AND DYNC2H1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARAP1

GO:0043547

positive regulation of GTPase activity

11804590

TgeneDYNC2H1

GO:0007030

Golgi organization

8666668


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A3EV-06AARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000359373ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000359373ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000359373ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-3CDSENST00000495878ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000495878ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000495878ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-3CDSENST00000455638ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000455638ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000455638ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-3CDSENST00000393605ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000393605ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000393605ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-3CDSENST00000334211ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-intronENST00000334211ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-intronENST00000334211ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-3CDSENST00000393609ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000393609ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
intron-intronENST00000393609ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-3CDSENST00000426523ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-intronENST00000426523ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-intronENST00000426523ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-3CDSENST00000429686ENST00000375735ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-intronENST00000429686ENST00000334267ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+
5UTR-intronENST00000429686ENST00000398093ARAP1chr11

72432895

-DYNC2H1chr11

103062246

+

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FusionProtFeatures for ARAP1_DYNC2H1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARAP1

Q96P48

DYNC2H1

Q8NCM8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ARAP1_DYNC2H1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ARAP1_DYNC2H1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARAP1ARPC3, XRCC6, FGFR3, ARIH2, SH3KBP1, INPP5D, KCTD12, PSD3, TP53BP1, TES, WAPAL, TAB1, UBASH3B, GRB2, SHC1, APP, VCAM1, CAPZA2, NCK2, NTRK1, HMGXB4, SNW1, FPR2, TRIM25DYNC2H1DYNC2LI1, USP50, PAXIP1, PEX14, FAM160B2, ARHGAP25, NONO, RUVBL2, GDI1, TIGD6, SPC24, PPP2R3C, GAN, EPHA1, FCGRT, CRYL1, MOCS3, IL17RA, KIAA1919, MTNR1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARAP1_DYNC2H1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARAP1_DYNC2H1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDYNC2H1C0036069Saldino-Noonan Syndrome4UNIPROT
TgeneDYNC2H1C0036996Short Rib-Polydactyly Syndrome1CTD_human
TgeneDYNC2H1C1458155Mammary Neoplasms1CTD_human