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Fusion gene ID: 22913 |
FusionGeneSummary for MVP_ZNF267 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MVP_ZNF267 | Fusion gene ID: 22913 | Hgene | Tgene | Gene symbol | MVP | ZNF267 | Gene ID | 9961 | 10308 |
| Gene name | major vault protein | zinc finger protein 267 | |
| Synonyms | LRP|VAULT1 | HZF2 | |
| Cytomap | 16p11.2 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | major vault proteinlung resistance-related proteintesticular secretory protein Li 30 | zinc finger protein 267zinc finger (C2H2)zinc finger protein 2zinc finger protein HZF2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q14764 | Q14586 | |
| Ensembl transtripts involved in fusion gene | ENST00000357402, ENST00000452209, ENST00000395353, ENST00000566554, | ENST00000300870, ENST00000394846, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MVP [Title/Abstract] AND ZNF267 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MVP | GO:0023057 | negative regulation of signaling | 16441665 |
| Hgene | MVP | GO:0031953 | negative regulation of protein autophosphorylation | 16441665 |
| Hgene | MVP | GO:0038127 | ERBB signaling pathway | 15133037 |
| Hgene | MVP | GO:0061099 | negative regulation of protein tyrosine kinase activity | 16441665 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CR-6474-01A | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000357402 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| 5CDS-3UTR | ENST00000357402 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| intron-3CDS | ENST00000452209 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| intron-3UTR | ENST00000452209 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| Frame-shift | ENST00000395353 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| 5CDS-3UTR | ENST00000395353 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| intron-3CDS | ENST00000566554 | ENST00000300870 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
| intron-3UTR | ENST00000566554 | ENST00000394846 | MVP | chr16 | 29842394 | + | ZNF267 | chr16 | 31925797 | + |
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FusionProtFeatures for MVP_ZNF267 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MVP | ZNF267 |