|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22839 |
FusionGeneSummary for MTSS1_ERBB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTSS1_ERBB2 | Fusion gene ID: 22839 | Hgene | Tgene | Gene symbol | MTSS1 | ERBB2 | Gene ID | 9788 | 2064 |
| Gene name | MTSS1, I-BAR domain containing | erb-b2 receptor tyrosine kinase 2 | |
| Synonyms | MIM|MIMA|MIMB | CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1 | |
| Cytomap | 8q24.13 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | metastasis suppressor protein 1metastasis suppressor 1metastasis suppressor YGL-1missing in metastasis protein | receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | O43312 | P04626 | |
| Ensembl transtripts involved in fusion gene | ENST00000378017, ENST00000518547, ENST00000354184, ENST00000395508, ENST00000325064, ENST00000431961, ENST00000523587, ENST00000524090, | ENST00000584601, ENST00000406381, ENST00000541774, ENST00000445658, ENST00000540147, ENST00000584450, ENST00000269571, ENST00000578199, ENST00000540042, ENST00000584888, | |
| Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 17 X 14 X 7=1666 |
| # samples | 8 | 18 | |
| ** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1666*10)=-3.21031958903587 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MTSS1 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ERBB2 | GO:0007165 | signal transduction | 10572067 |
| Tgene | ERBB2 | GO:0007166 | cell surface receptor signaling pathway | 9685399 |
| Tgene | ERBB2 | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 7514177 |
| Tgene | ERBB2 | GO:0014065 | phosphatidylinositol 3-kinase signaling | 7556068 |
| Tgene | ERBB2 | GO:0032886 | regulation of microtubule-based process | 20937854 |
| Tgene | ERBB2 | GO:0042060 | wound healing | 12646923 |
| Tgene | ERBB2 | GO:0043406 | positive regulation of MAP kinase activity | 10572067 |
| Tgene | ERBB2 | GO:0045785 | positive regulation of cell adhesion | 7556068 |
| Tgene | ERBB2 | GO:0045945 | positive regulation of transcription by RNA polymerase III | 19372587 |
| Tgene | ERBB2 | GO:0046777 | protein autophosphorylation | 7556068 |
| Tgene | ERBB2 | GO:0050679 | positive regulation of epithelial cell proliferation | 10572067 |
| Tgene | ERBB2 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
| Tgene | ERBB2 | GO:0090314 | positive regulation of protein targeting to membrane | 20010870 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-DK-A2I6-01A | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000378017 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000378017 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000378017 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-intron | ENST00000378017 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000378017 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000378017 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000378017 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000378017 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000378017 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-intron | ENST00000378017 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-intron | ENST00000518547 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000518547 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-intron | ENST00000518547 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-intron | ENST00000354184 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-5UTR | ENST00000354184 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5UTR-intron | ENST00000354184 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000395508 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000395508 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000395508 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-intron | ENST00000325064 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-5UTR | ENST00000325064 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| 5CDS-intron | ENST00000325064 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000431961 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000431961 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000431961 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000523587 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000523587 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000523587 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000584601 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000406381 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000541774 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000524090 | ENST00000445658 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000540147 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000584450 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000269571 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000578199 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-5UTR | ENST00000524090 | ENST00000540042 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
| intron-intron | ENST00000524090 | ENST00000584888 | MTSS1 | chr8 | 125740125 | - | ERBB2 | chr17 | 37863243 | + |
Top |
FusionProtFeatures for MTSS1_ERBB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTSS1 | ERBB2 |