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Fusion gene ID: 22806

FusionGeneSummary for MTMR3_ZNRF3

Fusion gene summary

Fusion gene information	Fusion gene name: MTMR3_ZNRF3
	Fusion gene ID: 22806
		Hgene	Tgene
	Gene symbol	MTMR3	ZNRF3
	Gene ID	8897	84133
	Gene name	myotubularin related protein 3	zinc and ring finger 3
	Synonyms	FYVE-DSP1\|ZFYVE10	BK747E2.3\|RNF203
	Cytomap	22q12.2	22q12.1
	Type of gene	protein-coding	protein-coding
	Description	myotubularin-related protein 3FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphataseFYVE domain-containing dual specificity protein phosphatase 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate pho	E3 ubiquitin-protein ligase ZNRF3CTA-292E10.6RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3novel C3HC4 type Zinc finger (ring finger)zinc/RING finger protein 3
	Modification date	20180519	20180523
	UniProtAcc	Q13615	Q9ULT6
	Ensembl transtripts involved in fusion gene	ENST00000401950, ENST00000333027, ENST00000323630, ENST00000351488, ENST00000406629, ENST00000415511,	ENST00000544604, ENST00000332811, ENST00000402174, ENST00000406323,
Fusion gene scores	* DoF score	12 X 5 X 9=540	7 X 6 X 6=252
	# samples	15	9
	** MAII score	log2(15/540*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: MTMR3 [Title/Abstract] AND ZNRF3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MTMR3	GO:0006470	protein dephosphorylation	10733931
Hgene	MTMR3	GO:0046856	phosphatidylinositol dephosphorylation	10900271\|11676921
Hgene	MTMR3	GO:0060304	regulation of phosphatidylinositol dephosphorylation	16787938
Hgene	MTMR3	GO:1904562	phosphatidylinositol 5-phosphate metabolic process	11676921
Tgene	ZNRF3	GO:0016567	protein ubiquitination	22575959

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LIHC	TCGA-DD-A118-01A	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
TCGA	LD	OV	TCGA-36-1575-01A	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000401950	ENST00000544604	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000401950	ENST00000332811	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000401950	ENST00000402174	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000401950	ENST00000406323	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000333027	ENST00000544604	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000333027	ENST00000332811	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000333027	ENST00000402174	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000333027	ENST00000406323	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000323630	ENST00000544604	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000323630	ENST00000332811	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000323630	ENST00000402174	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000323630	ENST00000406323	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000351488	ENST00000544604	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000351488	ENST00000332811	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000351488	ENST00000402174	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
5UTR-3CDS	ENST00000351488	ENST00000406323	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
intron-3CDS	ENST00000406629	ENST00000544604	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
intron-3CDS	ENST00000406629	ENST00000332811	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
intron-3CDS	ENST00000406629	ENST00000402174	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
intron-3CDS	ENST00000406629	ENST00000406323	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
3UTR-3CDS	ENST00000415511	ENST00000544604	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
3UTR-3CDS	ENST00000415511	ENST00000332811	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
3UTR-3CDS	ENST00000415511	ENST00000402174	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+
3UTR-3CDS	ENST00000415511	ENST00000406323	MTMR3	chr22	30279348	+	ZNRF3	chr22	29383064	+

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FusionProtFeatures for MTMR3_ZNRF3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTMR3 Q13615	ZNRF3 Q9ULT6

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Fusion gene ID: 22806

FusionGeneSummary for MTMR3_ZNRF3

FusionProtFeatures for MTMR3_ZNRF3