|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22788 |
FusionGeneSummary for MTMR1_ZC3HC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTMR1_ZC3HC1 | Fusion gene ID: 22788 | Hgene | Tgene | Gene symbol | MTMR1 | ZC3HC1 | Gene ID | 8776 | 51530 |
| Gene name | myotubularin related protein 1 | zinc finger C3HC-type containing 1 | |
| Synonyms | - | HSPC216|NIPA | |
| Cytomap | Xq28 | 7q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myotubularin-related protein 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate phosphatase | nuclear-interacting partner of ALKhematopoietic stem/progenitor cell protein 216nuclear interacting partner of anaplastic lymphoma kinase (ALK) | |
| Modification date | 20180519 | 20180529 | |
| UniProtAcc | Q13613 | Q86WB0 | |
| Ensembl transtripts involved in fusion gene | ENST00000541925, ENST00000542156, ENST00000370390, ENST00000451863, ENST00000544228, ENST00000445323, ENST00000538506, | ENST00000358303, ENST00000360708, ENST00000311873, ENST00000481503, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 4=36 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MTMR1 [Title/Abstract] AND ZC3HC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MTMR1 | GO:0046856 | phosphatidylinositol dephosphorylation | 11733541|27018598 |
| Hgene | MTMR1 | GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 16787938 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF365539 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000541925 | ENST00000358303 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000541925 | ENST00000360708 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000541925 | ENST00000311873 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000541925 | ENST00000481503 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000542156 | ENST00000358303 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000542156 | ENST00000360708 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000542156 | ENST00000311873 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000542156 | ENST00000481503 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000370390 | ENST00000358303 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000370390 | ENST00000360708 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000370390 | ENST00000311873 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000370390 | ENST00000481503 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000451863 | ENST00000358303 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000451863 | ENST00000360708 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000451863 | ENST00000311873 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000451863 | ENST00000481503 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000544228 | ENST00000358303 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000544228 | ENST00000360708 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000544228 | ENST00000311873 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000544228 | ENST00000481503 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000445323 | ENST00000358303 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000445323 | ENST00000360708 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000445323 | ENST00000311873 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000445323 | ENST00000481503 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000538506 | ENST00000358303 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000538506 | ENST00000360708 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000538506 | ENST00000311873 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
| intron-intron | ENST00000538506 | ENST00000481503 | MTMR1 | chrX | 149880963 | - | ZC3HC1 | chr7 | 129677752 | - |
Top |
FusionProtFeatures for MTMR1_ZC3HC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTMR1 | ZC3HC1 |