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Fusion gene ID: 22745

FusionGeneSummary for MTF2_FNBP1L

Fusion gene summary

Fusion gene information	Fusion gene name: MTF2_FNBP1L
	Fusion gene ID: 22745
		Hgene	Tgene
	Gene symbol	MTF2	FNBP1L
	Gene ID	22823	54874
	Gene name	metal response element binding transcription factor 2	formin binding protein 1 like
	Synonyms	M96\|PCL2\|TDRD19A\|dJ976O13.2	C1orf39\|TOCA1
	Cytomap	1p22.1	1p22.1
	Type of gene	protein-coding	protein-coding
	Description	metal-response element-binding transcription factor 2hPCl2metal regulatory transcription factor 2metal-response element DNA-binding protein M96polycomb-like 2polycomb-like protein 2putative DNA binding proteintudor domain containing 19A	formin-binding protein 1-liketoca-1transducer of Cdc42-dependent actin assembly 1transducer of Cdc42-dependent actin assembly protein 1
	Modification date	20180523	20180522
	UniProtAcc	Q9Y483	Q5T0N5
	Ensembl transtripts involved in fusion gene	ENST00000545708, ENST00000540243, ENST00000370298, ENST00000471953, ENST00000370303,	ENST00000370256, ENST00000260506, ENST00000271234, ENST00000604705, ENST00000370253,
Fusion gene scores	* DoF score	7 X 3 X 4=84	3 X 3 X 2=18
	# samples	8	3
	** MAII score	log2(8/84*10)=-0.070389327891398 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: MTF2 [Title/Abstract] AND FNBP1L [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FNBP1L	GO:0006900	vesicle budding from membrane	20730103
Tgene	FNBP1L	GO:0010324	membrane invagination	20730103
Tgene	FNBP1L	GO:0016050	vesicle organization	20730103
Tgene	FNBP1L	GO:0030050	vesicle transport along actin filament	20730103
Tgene	FNBP1L	GO:0051491	positive regulation of filopodium assembly	20730103
Tgene	FNBP1L	GO:0072583	clathrin-dependent endocytosis	20730103
Tgene	FNBP1L	GO:0097320	plasma membrane tubulation	20730103

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-E2-A1LL-01A	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000545708	ENST00000370256	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000545708	ENST00000260506	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000545708	ENST00000271234	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000545708	ENST00000604705	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000545708	ENST00000370253	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000540243	ENST00000370256	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000540243	ENST00000260506	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000540243	ENST00000271234	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000540243	ENST00000604705	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
5UTR-3CDS	ENST00000540243	ENST00000370253	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370298	ENST00000370256	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370298	ENST00000260506	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370298	ENST00000271234	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370298	ENST00000604705	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370298	ENST00000370253	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
3UTR-3CDS	ENST00000471953	ENST00000370256	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
3UTR-3CDS	ENST00000471953	ENST00000260506	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
3UTR-3CDS	ENST00000471953	ENST00000271234	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
3UTR-3CDS	ENST00000471953	ENST00000604705	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
3UTR-3CDS	ENST00000471953	ENST00000370253	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370303	ENST00000370256	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370303	ENST00000260506	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370303	ENST00000271234	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370303	ENST00000604705	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+
In-frame	ENST00000370303	ENST00000370253	MTF2	chr1	93545088	+	FNBP1L	chr1	93987639	+

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FusionProtFeatures for MTF2_FNBP1L

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MTF2 Q9Y483	FNBP1L Q5T0N5

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Fusion gene ID: 22745

FusionGeneSummary for MTF2_FNBP1L

FusionProtFeatures for MTF2_FNBP1L