|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22718 |
FusionGeneSummary for MTCH1_C3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MTCH1_C3 | Fusion gene ID: 22718 | Hgene | Tgene | Gene symbol | MTCH1 | C3 | Gene ID | 23787 | 718 |
| Gene name | mitochondrial carrier 1 | complement C3 | |
| Synonyms | CGI-64|PIG60|PSAP|SLC25A49 | AHUS5|ARMD9|ASP|C3a|C3b|CPAMD1|HEL-S-62p | |
| Cytomap | 6p21.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitochondrial carrier homolog 1cell proliferation-inducing protein 60presenilin-associated proteinsolute carrier family 25, member 49 | complement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1C3a anaphylatoxinacylation-stimulating protein cleavage productcomplement component 3complement component C3acomplement component C3bepididymis secretory sperm binding pr | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9NZJ7 | P01024 | |
| Ensembl transtripts involved in fusion gene | ENST00000373627, ENST00000373616, ENST00000471737, ENST00000538808, | ENST00000245907, ENST00000599668, | |
| Fusion gene scores | * DoF score | 4 X 5 X 1=20 | 14 X 13 X 6=1092 |
| # samples | 5 | 14 | |
| ** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/1092*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MTCH1 [Title/Abstract] AND C3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | C3 | GO:0001934 | positive regulation of protein phosphorylation | 15833747 |
| Tgene | C3 | GO:0010575 | positive regulation of vascular endothelial growth factor production | 16452172 |
| Tgene | C3 | GO:0010828 | positive regulation of glucose transmembrane transport | 9059512|15833747 |
| Tgene | C3 | GO:0010866 | regulation of triglyceride biosynthetic process | 10432298 |
| Tgene | C3 | GO:0010884 | positive regulation of lipid storage | 9555951 |
| Tgene | C3 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 15833747 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA169517 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000373627 | ENST00000245907 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| intron-intron | ENST00000373627 | ENST00000599668 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| intron-3CDS | ENST00000373616 | ENST00000245907 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| intron-intron | ENST00000373616 | ENST00000599668 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| intron-3CDS | ENST00000471737 | ENST00000245907 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| intron-intron | ENST00000471737 | ENST00000599668 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| intron-3CDS | ENST00000538808 | ENST00000245907 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
| intron-intron | ENST00000538808 | ENST00000599668 | MTCH1 | chr6 | 36949310 | - | C3 | chr19 | 6684452 | - |
Top |
FusionProtFeatures for MTCH1_C3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MTCH1 | C3 |