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Fusion gene ID: 22645 |
FusionGeneSummary for MSI2_TRIM25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSI2_TRIM25 | Fusion gene ID: 22645 | Hgene | Tgene | Gene symbol | MSI2 | TRIM25 | Gene ID | 124540 | 7706 |
| Gene name | musashi RNA binding protein 2 | tripartite motif containing 25 | |
| Synonyms | MSI2H | EFP|RNF147|Z147|ZNF147 | |
| Cytomap | 17q22 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein Musashi homolog 2musashi homolog 2musashi-2 | E3 ubiquitin/ISG15 ligase TRIM25RING finger protein 147RING-type E3 ubiquitin transferaseRING-type E3 ubiquitin transferase TRIM25estrogen-responsive finger proteintripartite motif protein TRIM25tripartite motif-containing protein 25ubiquitin/ISG15 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q96DH6 | Q14258 | |
| Ensembl transtripts involved in fusion gene | ENST00000416426, ENST00000284073, ENST00000322684, ENST00000442934, ENST00000579180, ENST00000579505, | ENST00000316881, ENST00000573108, ENST00000537230, | |
| Fusion gene scores | * DoF score | 29 X 8 X 12=2784 | 4 X 5 X 2=40 |
| # samples | 29 | 5 | |
| ** MAII score | log2(29/2784*10)=-3.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MSI2 [Title/Abstract] AND TRIM25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRIM25 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
| Tgene | TRIM25 | GO:0043627 | response to estrogen | 22452784 |
| Tgene | TRIM25 | GO:0045087 | innate immune response | 18248090 |
| Tgene | TRIM25 | GO:0046596 | regulation of viral entry into host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A12M-01A | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000416426 | ENST00000316881 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| 5CDS-intron | ENST00000416426 | ENST00000573108 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| 5CDS-intron | ENST00000416426 | ENST00000537230 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| In-frame | ENST00000284073 | ENST00000316881 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| 5CDS-intron | ENST00000284073 | ENST00000573108 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| 5CDS-intron | ENST00000284073 | ENST00000537230 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| In-frame | ENST00000322684 | ENST00000316881 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| 5CDS-intron | ENST00000322684 | ENST00000573108 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| 5CDS-intron | ENST00000322684 | ENST00000537230 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-3CDS | ENST00000442934 | ENST00000316881 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-intron | ENST00000442934 | ENST00000573108 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-intron | ENST00000442934 | ENST00000537230 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-3CDS | ENST00000579180 | ENST00000316881 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-intron | ENST00000579180 | ENST00000573108 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-intron | ENST00000579180 | ENST00000537230 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-3CDS | ENST00000579505 | ENST00000316881 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-intron | ENST00000579505 | ENST00000573108 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
| intron-intron | ENST00000579505 | ENST00000537230 | MSI2 | chr17 | 55339553 | + | TRIM25 | chr17 | 54985924 | - |
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FusionProtFeatures for MSI2_TRIM25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSI2 | TRIM25 |