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Fusion gene ID: 22619 |
FusionGeneSummary for MSH6_TEKT4P2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSH6_TEKT4P2 | Fusion gene ID: 22619 | Hgene | Tgene | Gene symbol | MSH6 | TEKT4P2 | Gene ID | 2956 | 100132288 |
| Gene name | mutS homolog 6 | tektin 4 pseudogene 2 | |
| Synonyms | GTBP|GTMBP|HNPCC5|HSAP|p160 | MAFIPL|TEKT4P | |
| Cytomap | 2p16.3 | 21p11.2 | |
| Type of gene | protein-coding | pseudo | |
| Description | DNA mismatch repair protein Msh6G/T mismatch-binding proteinmutS protein homolog 6mutS-alpha 160 kDa subunitsperm-associated protein | Tektin-4 like protein LOC389833 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P52701 | ||
| Ensembl transtripts involved in fusion gene | ENST00000607272, ENST00000234420, ENST00000540021, ENST00000538136, | ENST00000416067, | |
| Fusion gene scores | * DoF score | 3 X 5 X 2=30 | 3 X 2 X 2=12 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MSH6 [Title/Abstract] AND TEKT4P2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MSH6 | GO:0006281 | DNA repair | 8942985 |
| Hgene | MSH6 | GO:0006298 | mismatch repair | 10871409|23622243 |
| Hgene | MSH6 | GO:0045910 | negative regulation of DNA recombination | 17715146 |
| Hgene | MSH6 | GO:0051096 | positive regulation of helicase activity | 17715146 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-60-2706-01A | MSH6 | chr2 | 48010632 | + | TEKT4P2 | chr21 | 9966380 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000607272 | ENST00000416067 | MSH6 | chr2 | 48010632 | + | TEKT4P2 | chr21 | 9966380 | - |
| 5CDS-5UTR | ENST00000234420 | ENST00000416067 | MSH6 | chr2 | 48010632 | + | TEKT4P2 | chr21 | 9966380 | - |
| intron-5UTR | ENST00000540021 | ENST00000416067 | MSH6 | chr2 | 48010632 | + | TEKT4P2 | chr21 | 9966380 | - |
| intron-5UTR | ENST00000538136 | ENST00000416067 | MSH6 | chr2 | 48010632 | + | TEKT4P2 | chr21 | 9966380 | - |
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FusionProtFeatures for MSH6_TEKT4P2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSH6 | TEKT4P2 |