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Fusion gene ID: 22613 |
FusionGeneSummary for MSH4_RABGGTB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSH4_RABGGTB | Fusion gene ID: 22613 | Hgene | Tgene | Gene symbol | MSH4 | RABGGTB | Gene ID | 4438 | 5876 |
| Gene name | mutS homolog 4 | Rab geranylgeranyltransferase subunit beta | |
| Synonyms | - | GGTB | |
| Cytomap | 1p31.1 | 1p31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mutS protein homolog 4hMSH4 | geranylgeranyl transferase type-2 subunit betaGGTase-II-betaRab geranylgeranyltransferase beta subunitrab GG transferase betarab GGTase betatype II protein geranyl-geranyltransferase subunit beta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15457 | P53611 | |
| Ensembl transtripts involved in fusion gene | ENST00000263187, | ENST00000535300, ENST00000496055, ENST00000319942, ENST00000370826, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MSH4 [Title/Abstract] AND RABGGTB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A3QQ-01A | MSH4 | chr1 | 76288266 | + | RABGGTB | chr1 | 76260898 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000263187 | ENST00000535300 | MSH4 | chr1 | 76288266 | + | RABGGTB | chr1 | 76260898 | + |
| 5CDS-intron | ENST00000263187 | ENST00000496055 | MSH4 | chr1 | 76288266 | + | RABGGTB | chr1 | 76260898 | + |
| 5CDS-intron | ENST00000263187 | ENST00000319942 | MSH4 | chr1 | 76288266 | + | RABGGTB | chr1 | 76260898 | + |
| 5CDS-intron | ENST00000263187 | ENST00000370826 | MSH4 | chr1 | 76288266 | + | RABGGTB | chr1 | 76260898 | + |
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FusionProtFeatures for MSH4_RABGGTB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSH4 | RABGGTB |