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Fusion gene ID: 22611 |
FusionGeneSummary for MSH3_MSH3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MSH3_MSH3 | Fusion gene ID: 22611 | Hgene | Tgene | Gene symbol | MSH3 | MSH3 | Gene ID | 4437 | 4437 |
| Gene name | mutS homolog 3 | mutS homolog 3 | |
| Synonyms | DUP|FAP4|MRP1 | DUP|FAP4|MRP1 | |
| Cytomap | 5q14.1 | 5q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA mismatch repair protein Msh3divergent upstream proteinhMSH3mismatch repair protein 1 | DNA mismatch repair protein Msh3divergent upstream proteinhMSH3mismatch repair protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P20585 | P20585 | |
| Ensembl transtripts involved in fusion gene | ENST00000265081, ENST00000512258, | ENST00000265081, ENST00000512258, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 1 X 2 X 1=2 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/2*10)=3.32192809488736 | |
| Context | PubMed: MSH3 [Title/Abstract] AND MSH3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MSH3 | GO:0006281 | DNA repair | 8942985 |
| Hgene | MSH3 | GO:0045910 | negative regulation of DNA recombination | 17715146 |
| Hgene | MSH3 | GO:0051096 | positive regulation of helicase activity | 17715146 |
| Tgene | MSH3 | GO:0006281 | DNA repair | 8942985 |
| Tgene | MSH3 | GO:0045910 | negative regulation of DNA recombination | 17715146 |
| Tgene | MSH3 | GO:0051096 | positive regulation of helicase activity | 17715146 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA846951 | MSH3 | chr5 | 80172560 | + | MSH3 | chr5 | 80172620 | - | ||
| ChiTaRS3.1 | BE080139 | MSH3 | chr5 | 80037367 | + | MSH3 | chr5 | 80021268 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000265081 | ENST00000265081 | MSH3 | chr5 | 80172560 | + | MSH3 | chr5 | 80172620 | - |
| intron-intron | ENST00000265081 | ENST00000512258 | MSH3 | chr5 | 80172560 | + | MSH3 | chr5 | 80172620 | - |
| intron-intron | ENST00000512258 | ENST00000265081 | MSH3 | chr5 | 80172560 | + | MSH3 | chr5 | 80172620 | - |
| intron-intron | ENST00000512258 | ENST00000512258 | MSH3 | chr5 | 80172560 | + | MSH3 | chr5 | 80172620 | - |
| Frame-shift | ENST00000265081 | ENST00000265081 | MSH3 | chr5 | 80037367 | + | MSH3 | chr5 | 80021268 | + |
| 5CDS-3UTR | ENST00000265081 | ENST00000512258 | MSH3 | chr5 | 80037367 | + | MSH3 | chr5 | 80021268 | + |
| 3UTR-3CDS | ENST00000512258 | ENST00000265081 | MSH3 | chr5 | 80037367 | + | MSH3 | chr5 | 80021268 | + |
| 3UTR-3UTR | ENST00000512258 | ENST00000512258 | MSH3 | chr5 | 80037367 | + | MSH3 | chr5 | 80021268 | + |
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FusionProtFeatures for MSH3_MSH3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MSH3 | MSH3 |