|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22550 |
FusionGeneSummary for MRPS22_CMPK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPS22_CMPK1 | Fusion gene ID: 22550 | Hgene | Tgene | Gene symbol | MRPS22 | CMPK1 | Gene ID | 56945 | 51727 |
| Gene name | mitochondrial ribosomal protein S22 | cytidine/uridine monophosphate kinase 1 | |
| Synonyms | C3orf5|COXPD5|GIBT|GK002|MRP-S22|RPMS22 | CK|CMK|CMPK|UMK|UMP-CMPK|UMPK | |
| Cytomap | 3q23 | 1p33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 28S ribosomal protein S22, mitochondrialS22mtmitochondrial small ribosomal subunit protein mS22 | UMP-CMP kinaseUMP/CMP kinasecytidine monophosphate (UMP-CMP) kinase 1, cytosoliccytidylate kinasedCMP kinasedeoxycytidylate kinasenucleoside-diphosphate kinaseuridine monophosphate kinaseuridine monophosphate/cytidine monophosphate kinase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P82650 | P30085 | |
| Ensembl transtripts involved in fusion gene | ENST00000495075, ENST00000310776, ENST00000465056, ENST00000478464, ENST00000489521, | ENST00000371873, ENST00000450808, ENST00000471289, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 5 X 3 X 3=45 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MRPS22 [Title/Abstract] AND CMPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CMPK1 | GO:0006165 | nucleoside diphosphate phosphorylation | 23416111 |
| Tgene | CMPK1 | GO:0009142 | nucleoside triphosphate biosynthetic process | 23416111 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK027204 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000495075 | ENST00000371873 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000495075 | ENST00000450808 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000495075 | ENST00000471289 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-3UTR | ENST00000310776 | ENST00000371873 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000310776 | ENST00000450808 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000310776 | ENST00000471289 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-3UTR | ENST00000465056 | ENST00000371873 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000465056 | ENST00000450808 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000465056 | ENST00000471289 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-3UTR | ENST00000478464 | ENST00000371873 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000478464 | ENST00000450808 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000478464 | ENST00000471289 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-3UTR | ENST00000489521 | ENST00000371873 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000489521 | ENST00000450808 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
| intron-intron | ENST00000489521 | ENST00000471289 | MRPS22 | chr3 | 139068439 | + | CMPK1 | chr1 | 47843702 | + |
Top |
FusionProtFeatures for MRPS22_CMPK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPS22 | CMPK1 |