|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 22527 |
FusionGeneSummary for MRPL52_C14orf93 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRPL52_C14orf93 | Fusion gene ID: 22527 | Hgene | Tgene | Gene symbol | MRPL52 | C14orf93 | Gene ID | 122704 | 60686 |
| Gene name | mitochondrial ribosomal protein L52 | chromosome 14 open reading frame 93 | |
| Synonyms | - | RTFC | |
| Cytomap | 14q11.2 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 39S ribosomal protein L52, mitochondrialL52mtMRP-L52mitochondrial large ribosomal subunit protein mL52 | uncharacterized protein C14orf93regulator of thyroid function and cancer | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q86TS9 | Q9H972 | |
| Ensembl transtripts involved in fusion gene | ENST00000355151, ENST00000397496, ENST00000555345, ENST00000432849, ENST00000553711, ENST00000397505, ENST00000557221, ENST00000311892, ENST00000556840, ENST00000461594, ENST00000555536, | ENST00000299088, ENST00000341470, ENST00000397379, ENST00000397382, ENST00000397377, ENST00000406429, ENST00000557513, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MRPL52 [Title/Abstract] AND C14orf93 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EE-A29V-06A | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000355151 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000355151 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000355151 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000355151 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000355151 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000355151 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000355151 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397496 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397496 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397496 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397496 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397496 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397496 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397496 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555345 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555345 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555345 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555345 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555345 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555345 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555345 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000432849 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000432849 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000432849 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000432849 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000432849 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000432849 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000432849 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000553711 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000553711 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000553711 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000553711 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000553711 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000553711 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000553711 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397505 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397505 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397505 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397505 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397505 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397505 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000397505 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000557221 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000557221 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000557221 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000557221 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000557221 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000557221 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5CDS-5UTR | ENST00000557221 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000311892 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000311892 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000311892 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000311892 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000311892 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000311892 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000311892 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000556840 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000556840 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000556840 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000556840 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000556840 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000556840 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000556840 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 3UTR-5UTR | ENST00000461594 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 3UTR-5UTR | ENST00000461594 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 3UTR-5UTR | ENST00000461594 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 3UTR-5UTR | ENST00000461594 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 3UTR-5UTR | ENST00000461594 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 3UTR-5UTR | ENST00000461594 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 3UTR-5UTR | ENST00000461594 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555536 | ENST00000299088 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555536 | ENST00000341470 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555536 | ENST00000397379 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555536 | ENST00000397382 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555536 | ENST00000397377 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555536 | ENST00000406429 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
| 5UTR-5UTR | ENST00000555536 | ENST00000557513 | MRPL52 | chr14 | 23299463 | + | C14orf93 | chr14 | 23468365 | - |
Top |
FusionProtFeatures for MRPL52_C14orf93 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRPL52 | C14orf93 |