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Fusion gene ID: 22431 |
FusionGeneSummary for MREG_DNAH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MREG_DNAH2 | Fusion gene ID: 22431 | Hgene | Tgene | Gene symbol | MREG | DNAH2 | Gene ID | 55686 | 146754 |
| Gene name | melanoregulin | dynein axonemal heavy chain 2 | |
| Synonyms | DSU|WDT2 | DNAHC2|DNHD3 | |
| Cytomap | 2q35 | 17p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | melanoregulindilute suppressor protein homologwhn-dependent transcript 2 | dynein heavy chain 2, axonemalaxonemal beta dynein heavy chain 2ciliary dynein heavy chain 2dynein heavy chain domain-containing protein 3dynein, axonemal, heavy polypeptide 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8N565 | Q9P225 | |
| Ensembl transtripts involved in fusion gene | ENST00000263268, | ENST00000572933, ENST00000389173, ENST00000570791, ENST00000082259, | |
| Fusion gene scores | * DoF score | 4 X 2 X 2=16 | 6 X 4 X 4=96 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/16*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MREG [Title/Abstract] AND DNAH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A8BM-01A | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7735897 | + |
| TCGA | LD | SARC | TCGA-DX-A8BM-01A | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7733618 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000263268 | ENST00000572933 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7735897 | + |
| In-frame | ENST00000263268 | ENST00000389173 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7735897 | + |
| 5CDS-intron | ENST00000263268 | ENST00000570791 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7735897 | + |
| 5CDS-intron | ENST00000263268 | ENST00000082259 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7735897 | + |
| In-frame | ENST00000263268 | ENST00000572933 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7733618 | + |
| In-frame | ENST00000263268 | ENST00000389173 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7733618 | + |
| 5CDS-intron | ENST00000263268 | ENST00000570791 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7733618 | + |
| 5CDS-intron | ENST00000263268 | ENST00000082259 | MREG | chr2 | 216877956 | - | DNAH2 | chr17 | 7733618 | + |
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FusionProtFeatures for MREG_DNAH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MREG | DNAH2 |