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Fusion gene ID: 22421 |
FusionGeneSummary for MRC2_PHYHIPL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRC2_PHYHIPL | Fusion gene ID: 22421 | Hgene | Tgene | Gene symbol | MRC2 | PHYHIPL | Gene ID | 9902 | 84457 |
| Gene name | mannose receptor C type 2 | phytanoyl-CoA 2-hydroxylase interacting protein like | |
| Synonyms | CD280|CLEC13E|ENDO180|UPARAP | - | |
| Cytomap | 17q23.2 | 10q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C-type mannose receptor 2C-type lectin domain family 13 member EUPAR-associated proteinendocytic receptor (macrophage mannose receptor family)endocytic receptor 180macrophage mannose receptor 2urokinase-type plasminogen activator receptor-associated | phytanoyl-CoA hydroxylase-interacting protein-like | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UBG0 | Q96FC7 | |
| Ensembl transtripts involved in fusion gene | ENST00000303375, ENST00000446119, ENST00000580916, | ENST00000373880, ENST00000433653, ENST00000373878, ENST00000472199, | |
| Fusion gene scores | * DoF score | 9 X 7 X 5=315 | 5 X 4 X 3=60 |
| # samples | 10 | 4 | |
| ** MAII score | log2(10/315*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MRC2 [Title/Abstract] AND PHYHIPL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MRC2 | GO:0030574 | collagen catabolic process | 12972549 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A8IC-01A | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000303375 | ENST00000373880 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| 5CDS-intron | ENST00000303375 | ENST00000433653 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| 5CDS-intron | ENST00000303375 | ENST00000373878 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| 5CDS-intron | ENST00000303375 | ENST00000472199 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-3CDS | ENST00000446119 | ENST00000373880 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-intron | ENST00000446119 | ENST00000433653 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-intron | ENST00000446119 | ENST00000373878 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-intron | ENST00000446119 | ENST00000472199 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-3CDS | ENST00000580916 | ENST00000373880 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-intron | ENST00000580916 | ENST00000433653 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-intron | ENST00000580916 | ENST00000373878 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
| intron-intron | ENST00000580916 | ENST00000472199 | MRC2 | chr17 | 60705281 | + | PHYHIPL | chr10 | 61004817 | + |
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FusionProtFeatures for MRC2_PHYHIPL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRC2 | PHYHIPL |