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Fusion gene ID: 22418 |
FusionGeneSummary for MRC1_ALOX5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MRC1_ALOX5 | Fusion gene ID: 22418 | Hgene | Tgene | Gene symbol | MRC1 | ALOX5 | Gene ID | 4360 | 240 |
| Gene name | mannose receptor C-type 1 | arachidonate 5-lipoxygenase | |
| Synonyms | CD206|CLEC13D|CLEC13DL|MMR|MRC1L1|bA541I19.1|hMR | 5-LO|5-LOX|5LPG|LOG5 | |
| Cytomap | 10p12.33 | 10q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | macrophage mannose receptor 1C-type lectin domain family 13 member Dhuman mannose receptormacrophage mannose receptor 1-like protein 1mannose receptor, C type 1-like 1 | arachidonate 5-lipoxygenaseLOX-5arachidonic 5-lipoxygenase alpha-10 isoformarachidonic 5-lipoxygenase delta-10-13 isoformarachidonic 5-lipoxygenase delta-13 isoformarachidonic 5-lipoxygenase delta-p10 isoformarachidonic acid 5-lipoxygenaseleukotrie | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P22897 | P09917 | |
| Ensembl transtripts involved in fusion gene | ENST00000239761, | ENST00000542434, ENST00000374391, ENST00000493336, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MRC1 [Title/Abstract] AND ALOX5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MRC1 | GO:0006898 | receptor-mediated endocytosis | 20035344 |
| Tgene | ALOX5 | GO:0019370 | leukotriene biosynthetic process | 21233389 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-MR-A8JO-01A | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000239761 | ENST00000542434 | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
| Frame-shift | ENST00000239761 | ENST00000374391 | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
| 5CDS-intron | ENST00000239761 | ENST00000493336 | MRC1 | chr10 | 18183241 | + | ALOX5 | chr10 | 45877931 | + |
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FusionProtFeatures for MRC1_ALOX5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MRC1 | ALOX5 |