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Fusion gene ID: 22405 |
FusionGeneSummary for MPST_WAS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPST_WAS | Fusion gene ID: 22405 | Hgene | Tgene | Gene symbol | MPST | WAS | Gene ID | 4357 | 7454 |
| Gene name | mercaptopyruvate sulfurtransferase | Wiskott-Aldrich syndrome | |
| Synonyms | MST|TST2|TUM1 | IMD2|SCNX|THC|THC1|WASP|WASPA | |
| Cytomap | 22q12.3 | Xp11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 3-mercaptopyruvate sulfurtransferasehuman liver rhodanesetRNA thiouridin modification protein 1testicular tissue protein Li 200 | wiskott-Aldrich syndrome proteineczema-thrombocytopeniathrombocytopenia 1 (X-linked) | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P25325 | P42768 | |
| Ensembl transtripts involved in fusion gene | ENST00000401419, ENST00000397129, ENST00000404802, ENST00000341116, ENST00000429360, ENST00000404393, ENST00000397225, | ENST00000376701, ENST00000483750, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/1*10)=4.32192809488736 | log2(2/1*10)=4.32192809488736 | |
| Context | PubMed: MPST [Title/Abstract] AND WAS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB164510 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + | ||
| ChiTaRS3.1 | CB157649 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000401419 | ENST00000376701 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-intron | ENST00000401419 | ENST00000483750 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-3CDS | ENST00000397129 | ENST00000376701 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-intron | ENST00000397129 | ENST00000483750 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-3CDS | ENST00000404802 | ENST00000376701 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-intron | ENST00000404802 | ENST00000483750 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-3CDS | ENST00000341116 | ENST00000376701 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-intron | ENST00000341116 | ENST00000483750 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-3CDS | ENST00000429360 | ENST00000376701 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-intron | ENST00000429360 | ENST00000483750 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-3CDS | ENST00000404393 | ENST00000376701 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-intron | ENST00000404393 | ENST00000483750 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-3CDS | ENST00000397225 | ENST00000376701 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
| 3UTR-intron | ENST00000397225 | ENST00000483750 | MPST | chr22 | 37425623 | - | WAS | chrX | 48547792 | + |
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FusionProtFeatures for MPST_WAS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPST | WAS |