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Fusion gene ID: 22393 |
FusionGeneSummary for MPRIP_COPS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPRIP_COPS3 | Fusion gene ID: 22393 | Hgene | Tgene | Gene symbol | MPRIP | COPS3 | Gene ID | 23164 | 8533 |
| Gene name | myosin phosphatase Rho interacting protein | COP9 signalosome subunit 3 | |
| Synonyms | M-RIP|MRIP|RHOIP3|RIP3|p116Rip | CSN3|SGN3 | |
| Cytomap | 17p11.2 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | myosin phosphatase Rho-interacting proteinRho interacting protein 3 | COP9 signalosome complex subunit 3COP9 complex subunit 3COP9 constitutive photomorphogenic homolog subunit 3JAB1-containing signalosome subunit 3signalosome subunit 3 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q6WCQ1 | Q9UNS2 | |
| Ensembl transtripts involved in fusion gene | ENST00000395811, ENST00000444976, ENST00000395804, ENST00000341712, ENST00000395806, ENST00000395807, | ENST00000539941, ENST00000268717, ENST00000439936, | |
| Fusion gene scores | * DoF score | 12 X 5 X 7=420 | 5 X 4 X 5=100 |
| # samples | 12 | 5 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MPRIP [Title/Abstract] AND COPS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | COPS3 | GO:0000338 | protein deneddylation | 19141280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-HE-A5NK-01A | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000395811 | ENST00000539941 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| Frame-shift | ENST00000395811 | ENST00000268717 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| In-frame | ENST00000395811 | ENST00000439936 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| Frame-shift | ENST00000444976 | ENST00000539941 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| Frame-shift | ENST00000444976 | ENST00000268717 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| In-frame | ENST00000444976 | ENST00000439936 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| Frame-shift | ENST00000395804 | ENST00000539941 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| Frame-shift | ENST00000395804 | ENST00000268717 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| In-frame | ENST00000395804 | ENST00000439936 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| Frame-shift | ENST00000341712 | ENST00000539941 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| Frame-shift | ENST00000341712 | ENST00000268717 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| In-frame | ENST00000341712 | ENST00000439936 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| intron-3CDS | ENST00000395806 | ENST00000539941 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| intron-3CDS | ENST00000395806 | ENST00000268717 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| intron-3CDS | ENST00000395806 | ENST00000439936 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| 3UTR-3CDS | ENST00000395807 | ENST00000539941 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| 3UTR-3CDS | ENST00000395807 | ENST00000268717 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
| 3UTR-3CDS | ENST00000395807 | ENST00000439936 | MPRIP | chr17 | 16981390 | + | COPS3 | chr17 | 17150465 | - |
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FusionProtFeatures for MPRIP_COPS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPRIP | COPS3 |