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Fusion gene ID: 2239

FusionGeneSummary for APOPT1_ASPG

Fusion gene summary

Fusion gene information	Fusion gene name: APOPT1_ASPG
	Fusion gene ID: 2239
		Hgene	Tgene
	Gene symbol	APOPT1	ASPG
	Gene ID	84334	374569
	Gene name	apoptogenic 1, mitochondrial	asparaginase
	Synonyms	APOP\|APOP1\|C14orf153	C14orf76\|GPA/WT
	Cytomap	14q32.33	14q32.33
	Type of gene	protein-coding	protein-coding
	Description	apoptogenic protein 1, mitochondrialUPF0671 protein C14orf153	60 kDa lysophospholipaseasparaginase homologwild-type L-asparaginase
	Modification date	20180523	20180523
	UniProtAcc	Q96IL0	Q86U10
	Ensembl transtripts involved in fusion gene	ENST00000409074, ENST00000556253, ENST00000247618, ENST00000477116,	ENST00000551177, ENST00000546892, ENST00000455920, ENST00000549809,
Fusion gene scores	* DoF score	4 X 3 X 4=48	1 X 1 X 1=1
	# samples	6	1
	** MAII score	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(1/1*10)=3.32192809488736
Context	PubMed: APOPT1 [Title/Abstract] AND ASPG [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUAD	TCGA-86-8358-01A	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000409074	ENST00000551177	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000409074	ENST00000546892	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000409074	ENST00000455920	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
5CDS-intron	ENST00000409074	ENST00000549809	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000556253	ENST00000551177	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000556253	ENST00000546892	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000556253	ENST00000455920	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
5CDS-intron	ENST00000556253	ENST00000549809	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000247618	ENST00000551177	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000247618	ENST00000546892	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
Frame-shift	ENST00000247618	ENST00000455920	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
5CDS-intron	ENST00000247618	ENST00000549809	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
3UTR-3CDS	ENST00000477116	ENST00000551177	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
3UTR-3CDS	ENST00000477116	ENST00000546892	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
3UTR-3CDS	ENST00000477116	ENST00000455920	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+
3UTR-intron	ENST00000477116	ENST00000549809	APOPT1	chr14	104040507	+	ASPG	chr14	104578257	+

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FusionProtFeatures for APOPT1_ASPG

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
APOPT1 Q96IL0	ASPG Q86U10

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Fusion gene ID: 2239

FusionGeneSummary for APOPT1_ASPG

FusionProtFeatures for APOPT1_ASPG