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Fusion gene ID: 22381 |
FusionGeneSummary for MPP5_TSTD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MPP5_TSTD3 | Fusion gene ID: 22381 | Hgene | Tgene | Gene symbol | MPP5 | TSTD3 | Gene ID | 64398 | 100130890 |
| Gene name | membrane palmitoylated protein 5 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 | |
| Synonyms | PALS1 | - | |
| Cytomap | 14q23.3 | 6q16.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAGUK p55 subfamily member 5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)protein associated with Lin-7 1protein associated with lin seven 1stardust | thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3rhodanese domain-containing protein 3 | |
| Modification date | 20180519 | 20180331 | |
| UniProtAcc | Q8N3R9 | ||
| Ensembl transtripts involved in fusion gene | ENST00000261681, ENST00000555925, ENST00000554911, ENST00000556345, | ENST00000452647, | |
| Fusion gene scores | * DoF score | 8 X 8 X 10=640 | 5 X 5 X 1=25 |
| # samples | 17 | 5 | |
| ** MAII score | log2(17/640*10)=-1.91253715874966 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MPP5 [Title/Abstract] AND TSTD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI049284 | MPP5 | chr14 | 67774205 | + | TSTD3 | chr6 | 100009276 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000261681 | ENST00000452647 | MPP5 | chr14 | 67774205 | + | TSTD3 | chr6 | 100009276 | + |
| intron-intron | ENST00000555925 | ENST00000452647 | MPP5 | chr14 | 67774205 | + | TSTD3 | chr6 | 100009276 | + |
| intron-intron | ENST00000554911 | ENST00000452647 | MPP5 | chr14 | 67774205 | + | TSTD3 | chr6 | 100009276 | + |
| intron-intron | ENST00000556345 | ENST00000452647 | MPP5 | chr14 | 67774205 | + | TSTD3 | chr6 | 100009276 | + |
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FusionProtFeatures for MPP5_TSTD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MPP5 | TSTD3 |